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  • 51.
    Sjödahl Hammarlund, Catharina
    et al.
    Department of Health Sciences, Lund University, Lund, Sweden.
    Hagell, Peter
    Kristianstad University, Research Environment PRO-CARE. Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap I. Kristianstad University, Research Platform for Collaboration for Health.
    Nilsson, Maria H
    Department of Health Sciences, Lund University, Lund, Sweden.
    Motoriska och icke-motoriska prediktorer för patientrapporterad distress vid Parkinsons sjukdom2012In: BestPractice Psykiatri/Neurologi, Vol. 3, no 12, p. 12-15Article, review/survey (Other academic)
  • 52.
    Sjödahl Hammarlund, Catharina
    et al.
    Department of Health Sciences, Lund University.
    Nilsson, Maria
    Department of Health Sciences, Lund University.
    Hagell, Peter
    Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap. Kristianstad University, Research Environment PRO-CARE.
    Measuring outcomes in Parkinson's disease: a multi-perspective concept mapping study2012In: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649, Vol. 21, no 3, p. 453-463Article in journal (Refereed)
    Abstract [en]

    To identify and develop a conceptual map of prioritized areas and to determine their relative importance for outcome measurement in clinical Parkinson's disease (PD) trials, from the perspectives of health care professionals and people with PD.

    METHOD:

    We used concept mapping, a qualitative/quantitative method consisting of three steps: item generation through focus groups (n = 27; 12 people with PD, 12 health care professionals, 3 researchers), item sorting and rating (n = 38; 19 people with PD, 19 health care professionals), and data analysis (multidimensional scaling, cluster analysis).

    RESULTS:

    Ninety-nine items and eight clusters were generated. Clusters representing Participation; Mobility and motor functioning; Cognitive and executive functioning; and Emotions were the most homogenous. Statements within clusters representing Energy and abilities; Autonomic dysfunctions; Sensory, speech and swallowing problems; and Neuropsychiatric symptoms also related to statements outside their respective clusters. Clusters rated most important were Participation and Mobility and motor functioning, and the highest rated items were quality of life, walking ability, and sleeping problems.

    CONCLUSION:

    By the use of concept mapping, a multi-perspective conceptual map of prioritized aspects for the outcome measurement in PD was defined. These findings provide an initial conceptual basis toward improved outcome measurement priorities in clinical PD trials.

  • 53.
    Sjödahl Hammarlund, Catharina
    et al.
    Kristianstad University, Faculty of Health Science, Research Environment PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Lund University.
    Westergren, Albert
    Kristianstad University, Faculty of Health Science, Research Environment PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Kristianstad University, Research Platform for Collaboration for Health. Kristianstad University, Faculty of Health Science, Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap.
    Åström, Ingrid
    Kristianstad University, Faculty of Health Science, Research Environment PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education.
    Edberg, Anna-Karin
    Kristianstad University, Research Platform for Collaboration for Health. Kristianstad University, Faculty of Health Science, Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap.
    Hagell, Peter
    Kristianstad University, Faculty of Health Science, Research Environment PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Kristianstad University, Research Platform for Collaboration for Health. Kristianstad University, Faculty of Health Science, Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap.
    The Impact of Living with Parkinson’s Disease: Balancing within a Web of Needs and Demands2018In: Parkinson's Disease, ISSN 2090-8083, E-ISSN 2042-0080, Vol. 2018, article id 4598651Article in journal (Refereed)
    Abstract [en]

    This study explores the impact of living with Parkinson’s disease (PD). Nineteen persons (11 women) aged 55–84 diagnosed with PD 3–27 years ago participated. Data were collected through semistructured interviews, which were recorded, transcribed verbatim, and analysed by qualitative content analysis. Four categories represented the impact of living with PD: “Changed prerequisites for managing day-to-day demands,” “Loss of identity and dignity,” “Compromised social participation,” and “The use of practical and psychological strategies.” There was a shift from an internal to an external locus of control in managing, control, competence, relatedness, and autonomy. According to self-determination theory, a shift towards extrinsically motivated behaviours may occur when these basic needs are thwarted, leading to compensatory strategies or needs substitutes with negative consequences on health and well-being. We suggest a needs-based approach as an important starting point to better understand the consequences of living with PD and to explore the means for people with PD to acquire an improved quality of life on their own terms. In conclusion, our findings suggest for a shift in focus, from a biomedical to a needs-based approach to understand the impact of living with PD and facilitate more person-centred care and person-centred outcome measurement.

  • 54.
    Westin, J.
    et al.
    Computer Science, Dalarna University.
    Stenberg, Georg
    Kristianstad University, School of Education and Environment, Avdelningen för Humanvetenskap. Kristianstad University, Forskningsmiljön ForFame.
    Development of a test for spatial working memory in Parkinson's disease: sensitivity to medication induced periodic performance changes2012In: European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331, Vol. 19, no Suppl. 1, p. 551-551Article in journal (Refereed)
    Abstract [en]

    Introduction: Spatial working memory is susceptible to impairment early on in Parkinson’s disease (PD). Later on, the wearing off phenomenon of motor function during dopaminergic treatment seems to carry over into working memory.

    Aim: To initialize development of a test capable of capturing the variation in spatial working memory within a patient’s daily functioning.

    Methods: The test consisted of 192 instances of n-back, yes/no tasks, with correctness and latency of response automatically recorded. We collected data from two persons, one PD patient and one healthy control, relatively evenly sampled regarding time-of-day. The patient took levodopa once every three hours and performed tests on 70 occasions (the healthy control on 33 occasions). A frequency band containing period lengths from 2 to 4 hours was defined as the region of interest in regard to the medication cycle. The resulting  time  series  were  digitally  band-pass  filtered allowing only the relevant frequencies to pass. Reasoning that filtering would preserve essential information if the time series were periodic, but eradicate it if they were not, we used as our primary outcome measure the correlations between filtered and unfiltered data.

    Results: Correlations between the pass-band relating to the levodopa intake schedule and the full data were positive and significantly larger for the patient than for the control. These differences applied to both latency and accuracy.

    Conclusion: This supports the hypothesis that the test is able to detect levodopa-dependent variations in spatial working memory.

  • 55.
    Ziyad, Riyam
    Kristianstad University, School of Education and Environment.
    Nervledningsstudie av suralisnerven och dess anatomiska variation2015Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med studien är att studera normala variationer i suralisnervens anatomi och utifrån detfastställa lämpligaste metoden för neurografi i kliniskt bruk. Vidare vill jag genom studien fåsvar på hur ålder och kroppslängd påverkar suralis sensoriska nerv aktion potential (SNAP)amplituden hos män och kvinnor, hur stimuleringslokationen påverka mätvärdena föramplitud och fortledningshastighet samt hur temperaturen påverkar fortledningshastigheten.Suralisnerven (SN) är den mest studerande sensoriska nerven i nedre extremiteterna hospatienter med perifer neuropati. Nervledningsstudier av SN är ett viktigt diagnostiskt verktygvid både axonal och demyeliniserande form av neuropatier. Det finns en stor spridning avnormalvärdena för SN eftersom den påverkas av olika parameter som ålder, kroppslängd ochhudtemperatur. SN är dessutom känd för sin anatomiska variation som gör att resultatetfeltolkas på grund av minskad eller frånvarande (SNAP).Fyrtio friska frivilliga personer deltog i studien. Medelålder för kvinnor var 47 (intervall 22-64) och 42 (intervall 25-54) för män. Nerven stimulerades från ett antal fördefinierade punkterpå distala halvan av vaden: medialt 14,12 och 10 cm från registretingselektroden och 2 cmlateralt från utgångspunkterna. Registrering utfördes från SN vid laterala malleolen.Studien kunde visa att SN amplitud påverkas av parameter som ålder, kön, kroppslängd ochtemperatur. Den största SNAP- amplituden registrerades från stimuleringsavstånd 10 cmmedialt och lateralt. Stimulering medialt gav större svar än stimulering lateralt.Parametrar som temperatur, ålder längd och köns påverkar normala variationer bland normalapatienter i nervledningsstudier. Studien visar att låga temperaturer ger minskadfortledningshastighet medan amplitudsvar ökar. Det är säkrare att stimulera nerven frånavstånd 10 cm medialt då risken för falskt positivt svar minimeras jämfört med avstånd 14cm. Det är viktigt att känna till suralisnervens anatomiska variationer inför mätningar vidundersökning av polyneuropati, eftersom resultaten annars kan misstolkas.

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