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  • 301.
    Ståhlnacke, Katri
    et al.
    Örebro County Council.
    Söderfeldt, Björn
    Department of oral public health, Malmö University.
    Unell, Lennart
    Örebro County Council.
    Halling, Arne
    Högskolan Kristianstad, Institutionen för hälsovetenskaper.
    Axtelius, Björn
    Department of oral public health, Malmö University.
    Patient satisfaction with dental care in one Swedish age cohort: part II - what affects satisfaction2007Ingår i: Swedish Dental Journal, ISSN 0347-9994, Vol. 31, nr 3, s. 137-146Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim of this study was to investigate satisfaction with dental care in relation to dental care factors, recent dental care experiences, past dental care experiences, general health factors, oral health factors and socio-economic factors and all over time. All persons born in 1942 in two counties in Sweden, Orebro and Ostergötland, were surveyed by post in 1992 at the age of 50, and resurveyed at the age 55. There were 5363 persons responding at both times, constituting the study group. A conceptual theoretical model was constructed to be used as a framework in the analysis. Multiple regression analysis and contingency tables were used. Factors related to satisfaction with dental care were: care organisation, cost for care, visit to dental specialist, time spent in waiting room, regular attendance, reception at dental clinic, feelings of anxiety, taking part of school dentistry, smoking, oral health factors, dental appearance and being dissatisfied 5 years previously. Change between the two study years was affected by perceived oral health, experiences from the most recent dental visit and care organisation. Oral health related factors and dental care factors like cost for care and care organisation were related to satisfaction with dental care. Likewise were experiences from the most recent dental visit and to some extent past care experiences like school dentistry. Almost no correlation was seen between socio-economic factors and satisfaction.

  • 302.
    Svard, Anna
    et al.
    Uppsala University.
    Renvert, Stefan
    Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL). Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för oral hälsa.
    Berglund, Johan
    Blekinge Inst Technology.
    Soderlin, Maria
    Lund University.
    Peridontitis and saliva antibodies to citrullinated peptides in rheumatoid arthtritis2019Ingår i: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 78, s. 1530-1530Artikel i tidskrift (Övrigt vetenskapligt)
  • 303. Swoboda, Jessica
    et al.
    Kiyak, H Asuman
    Persson, Rigmor E
    Persson, G. Rutger
    University of Washington, Seattle, Washington, USA.
    Yamaguchi, David K
    MacEntee, Michael I
    Wyatt, Christopher C L
    Predictors of oral health quality of life in older adults.2006Ingår i: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry, ISSN 0275-1879, Vol. 26, nr 4, s. 137-144Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    There is limited information regarding oral health status and other predictors of oral health-related quality of life. An association between oral health status and perceived oral health-related quality of life (OHQOL) might help clinicians motivate patients to prevent oral diseases and improve the outcome of some dental public health programs. This study evaluated the relationship between older persons' OHQOL and their functional dentition, caries, periodontal status, chronic diseases, and some demographic characteristics. A group of 733 low-income elders (mean age 72.7 [SD = 4.71, 55.6% women, 55.1% members of ethnic minority groups in the U.S. and Canada) enrolled in the TEETH clinical trial were interviewed and examined as part of their fifth annual visit for the trial. OHQOL was measured by the Geriatric Oral Health Assessment Index (GOHAI); oral health and occlusal status by clinical exams and the Eichner Index; and demographics via interviews. Elders who completed the four-year assessment had an average of 21.5 teeth (SD = 6.9), with 8.5 occluding pairs (SD = 4.6), and 32% with occlusal contacts in all four occluding zones. Stepwise multiple regressions were conducted to predict total GOHAI and its subscores (Physical, Social, and Worry). Functional dentition was a less significant predictor than ethnicity and being foreign-born. These variables, together with gender, years since immigrating, number of carious roots, and periodontal status, could predict 32% of the variance in total GOHAI, 24% in Physical, 27% in Social, and 21% in the Worry subscales. These findings suggest that functional dentition and caries influence older adults' OHQOL, but that ethnicity and immigrant status play a larger role.

  • 304. Swoboda, Jessica R
    et al.
    Kiyak, H Asuman
    Darveau, Richard
    Persson, G. Rutger
    University of Bern, Bern, Switzerland & University of Washington, Seattle, WA, USA.
    Correlates of periodontal decline and biologic markers in older adults.2008Ingår i: Journal of Periodontology, ISSN 0022-3492, E-ISSN 1943-3670, Vol. 79, nr 10, s. 1920-1926Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: There is limited information on infectious and host responses distinguishing older people with or without active periodontitis. This study measured bacterial and serum cytokine and high-sensitivity C-reactive protein (hsCRP) levels in older persons.

    METHODS: Elders (mean age: 67 years), whose periodontal status had declined most or least (20% worst or 20% best) over 5 years, were enrolled. Two years later, they were classified as periodontally declining (active periodontitis [AP]), if they had at least five teeth with probing depth (PD) > or =5 mm, or stable (stable periodontally [SP]), if they did not. Groups were compared with respect to demographics, PD, clinical loss of attachment, subgingival bacteria, serum hsCRP, interleukin (IL)-1beta and -6, and chronic diseases.

    RESULTS: Ten AP and 24 SP subjects were identified; 13% of women and 44% of men from the original sample were in the AP group (P <0.05). Most Asians were SP; most whites and all African Americans were classified as having AP (P <0.01). More AP elders had osteoporosis (P <0.01), but the AP and SP groups did not differ with respect to IL-1beta and -6 or hsCRP. Bacterial counts were higher in the AP group for Parvimonas micra (previously Peptostreptococcus micros or Micromonas micros) (7.7 x 10(5) cells versus 3.8 x 10(5) cells; P <0.05), Prevotella intermedia (25.7 x 10(5) cells versus 9.8 x 10(5) cells; P <0.01), Tannerella forsythia (previously T. forsythensis) (16.2 x 10(5) cells versus 8.0 x 10(5) cells; P <0.05), and Streptococcus mutans (6.2 x 10(5) cells versus 2.0 x 10(5) cells; P <0.01). Three risk factors were most predictive of periodontal decline: PD, osteoporosis, and being white or African American.

    CONCLUSION: Periodontal decline was associated with osteoporosis, ethnicity, PD, gender, serum hsCRP, and levels of four bacterial species.

  • 305.
    Särner, Barbro
    et al.
    Department of Cariology, Institute of Odontology, Sahlgrenska Academy at Göteborg University.
    Birkhed, D.
    Department of Cariology, Institute of Odontology, Sahlgrenska Academy at Göteborg University.
    Lingström, Peter
    Högskolan Kristianstad, Institutionen för hälsovetenskaper.
    Approximal fluoride concentration using different fluoridated products alone or in combination2008Ingår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 42, nr 1, s. 73-8Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim of the present investigation was to measure the approximal fluoride (F) concentration after using different F-containing products, either alone or in combination. Ten subjects participated on a total of 17 occasions, which were randomized, distributed and divided into two trials (called trial I and trial II). The F concentration was studied after treatment with toothpicks, dental flosses, an interdental brush dipped in 0.2 or 0.32% F gels, brushing with toothpaste containing 0.32% F and a mouthrinse with 0.2% NaF solution. The results of trial I revealed that the rinsing solution resulted in the highest approximal F values, followed by toothpicks and brushing. When brushing was combined with either flossing or toothpick, the sequence order of the two methods had less influence. However, when combined with rinsing it appeared to be better to use the floss or the toothpicks first, prior to the mouthrinse. In trial II, treatment with the gels alone, and in combination with brushing, resulted in higher approximal F concentrations compared with brushing alone. The data indicate that the order of usage when combining products may be of importance when it comes to obtaining high F levels at the approximal sites and that an interdental brush with F gel after toothbrushing may be a suitable method, called 'Inter Dental Brush Gel Method', to produce elevated F concentrations at approximal sites.

  • 306.
    Särner, Barbro
    et al.
    University of Gothenburg.
    Birkhed, Dowen
    University of Gothenburg.
    Andersson, Pia
    Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL). Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsplattformen för Hälsa i samverkan.
    Lingström, Peter
    University of Gothenburg.
    Recommendations by dental staff and use of toothpicks, dental floss and interdental brushes for approximal cleaning in an adult Swedish population2010Ingår i: Oral Health & Preventive Dentistry, ISSN 1602-1622, E-ISSN 1757-9996, Vol. 8, nr 2, s. 185-194Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: The aim of the present study was to evaluate the recommendations relating to the use of approximal cleaning aids given by dental hygienists and dentists, the self-care practices in a Swedish population and the ability to remove dental plaque. Materials and Methods: A structured questionnaire was randomly distributed to 500 dental hygienists and 500 dentists and a similar questionnaire was distributed to 1000 randomly selected individuals, divided equally into the following age groups: 15 to 20, 21 to 40, 41 to 60 and > 60 years. A clinical examination evaluating the ability to remove approximal dental plaque was also carried out in a total of 60 regular users of approximal cleaning aids. Plaque was scored before and after cleaning with a toothpick, dental floss or an interdental brush. Results: The response rate was 82%, 79% and 68% for the three groups. The results reveal that dental hygienists give more detailed information about a majority of the aspects that are related to the use of approximal cleaning aids compared with dentists (P < 0.01 or P < 0.001). The majority of the dental staff give recommendations to children and adolescents firstly to prevent dental caries and to older individuals to improve periodontal health. The use of different approximal cleaning aids on a daily basis varied with respect to age group (2% to 42%); dental floss dominated in the younger age groups and interdental brushes in the two oldest groups. In the clinical study, the largest plaque reduction was produced by the interdental brush (83%), followed by toothpicks (74%) and dental floss (73%). Conclusions: The present study indicated the importance of individual recommendations related to the use of approximal cleaning aids

  • 307.
    Takacs, Margareta
    et al.
    Högskolan Kristianstad, Sektionen för Hälsa och Samhälle.
    Svalin, Karin
    Högskolan Kristianstad, Sektionen för Hälsa och Samhälle.
    Kariessituationen hos äldre2011Självständigt arbete på grundnivå (kandidatexamen), 15 poäng / 22,5 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Eftersom medellivslängden ökar och de egna tänderna behålls högre upp i åldrarna finns det en ökad kariesrisk hos de äldre. Syftet med litteraturstudien var att redogöra för riskfaktorer som påverkar kariessituationen hos äldre personer. Ytterligare ett syfte var att ta reda på vilka tänder och tandytor som främst drabbas av karies. Studien genomfördes som en allmän litteraturstudie. Databaserna PubMed och Cinahl användes. Artiklar publicerade år 2000-2010 inkluderades. Total ingick 15 artiklar i resultatet. Resultatet visade att kost, mediciner, saliv, bakterier, gingivala retraktioner, egenvård, rökning, avtagbara proteser, protetiska kronor och antalet kvarvarande tänder var riskfaktorer som kunde orsaka både kron- och rotytekaries hos äldre. Rotytan, ocklusalytan och lingualytan samt de ytor som var belägna i direkt relation med lagningar var de ytor som främst drabbades av karies. De mest utsatta tänderna för kariesangrepp var molarerna, premolarerna samt caninerna. Många olika faktorer bidrar till en ökad kariesrisk hos äldre. Flertalet studier redovisade ett samband mellan gingivala retraktioner och rotytekaries. Majoriteten av det granskade materialet visade att rotytan var känslig för kariesangrepp. Framförallt var molarerna utsatta för kariesrisk hos äldre.

  • 308.
    Tonetti, Maurizio S
    et al.
    Kina.
    Bottenberg, Peter
    Belgien.
    Conrads, Georg
    Tyskland.
    Eickholz, Peter
    Tyskland.
    Heasman, Peter
    Storbritannien.
    Huysmans, Marie-Charlotte
    Nederländerna.
    López, Rodrigo
    Danmark.
    Madianos, Phoebus
    Grekland.
    Müller, Frauke
    Schweiz.
    Needleman, Ian
    Storbritannien.
    Nyvad, Bente
    Danmark.
    Preshaw, Philip M.
    Storbritannien.
    Pretty, Iain
    Storbritannien.
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    Schwendicke, Falk
    Tyskland.
    Trombelli, Leonardo
    Italien.
    van der Putten, Gert-Jan
    Nederländerna.
    Vanobbergen, Jacques
    Belgien.
    West, Nicola
    Storbritannien.
    Young, Alix
    Norge.
    Paris, Sebastian
    Tyskland.
    Dental caries and periodontal diseases in the ageing population: call to action to protect and enhance oral health and well-being as an essential component of healthy ageing - consensus report of group 4 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases.2017Ingår i: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 44, nr Suppl. 18, s. S135-S144Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Over the last two decades, progress in prevention and treatment of caries and periodontal diseases has been translated to better oral health and improved tooth retention in the adult population. The ageing population and the increasing expectations of good oral health-related quality of life in older age pose formidable challenges to clinical care and healthcare systems.

    AIMS: The objective of this workshop was to critically review scientific evidence and develop specific recommendations to: (i) prevent tooth loss and retain oral function through prevention and treatment of caries and periodontal diseases later in life and (ii) increase awareness of the health benefits of oral health as an essential component of healthy ageing.

    METHODS: Discussions were initiated by three systematic reviews covering aspects of epidemiology of caries and periodontal diseases in elders, the impact of senescence on caries and periodontal diseases and the effectiveness of interventions. Recommendations were developed based on evidence from the systematic reviews and expert opinion.

    RESULTS: Key messages included: (i) the ageing population, trends in risk factors and improved tooth retention point towards an expected increase in the total burden of disease posed by caries and periodontal diseases in the older population; (ii) specific surveillance is required to monitor changes in oral health in the older population; (iii) senescence impacts oral health including periodontitis and possibly caries susceptibility; (iv) evidence indicates that caries and periodontal diseases can be prevented and treated also in older adults; (v) oral health and functional tooth retention later in life provides benefits both in terms of oral and general quality of life and in terms of preventing physical decline and dependency by fostering a healthy diet; (vi) oral healthcare professionals and individuals should not base decisions impacting tooth retention on chronological age but on level of dependency, life expectancy, frailty, comfort and quality of life; and (vii) health policy should remove barriers to oral health care for vulnerable elders.

    CONCLUSIONS: Consensus was reached on specific actionable priorities for public health officials, oral healthcare professionals, educators and workforce planners, caregivers and relatives as well as for the public and ageing patients. Some priorities have major implications for policymakers as health systems need to adapt to the challenge by systemwide changes to enable (promote) tooth retention later in life and management of deteriorating oral health in increasingly dependent elders.

  • 309. Tonetti, Maurizio S
    et al.
    Jepsen, Søren
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    Clinical efficacy of periodontal plastic surgery procedures: consensus report of Group 2 of the 10th European Workshop on Periodontology2014Ingår i: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 41 Suppl 15, s. S36-43Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    AIM: The scope of the discussions of this consensus report was to assess the strength of the scientific evidence and make clinical and research recommendations for surgical interventions to cover exposed root surfaces and enhance soft tissues at implants.

    METHODS: Discussions were informed by three systematic reviews covering single recessions, multiple recessions and soft-tissue deficiencies at implants. The strength of the evidence was assessed using a modification in GRADE. The group also emphasized the need to report the experience of the surgeon and the performance of the control intervention (CONSORT guidelines for non-pharmacological treatment).

    RESULTS: A moderate strength of evidence supported the following statements for single (moderately deep, mostly maxillary) recessions without inter-dental attachment loss: (i) The addition of a connective tissue graft (CTG) improved outcomes of coronally advanced flaps (CAF). (ii) The addition of enamel matrix derivative (EMD) improved the outcomes of CAF. For multiple recessions, preliminary data indicate that flaps specifically designed to treat this condition are worthy of additional attention. Emerging data indicate that it is possible to obtain complete root coverage at sites with some inter-dental attachment loss. With regards to soft-tissue deficiencies at implants, several procedures are available, but great heterogeneity among studies does not allow drawing conclusions at this time.

    CONCLUSIONS: The group highlighted that periodontal plastic procedures are complex, technique-sensitive interventions that require advanced skills and expertise. At single recessions, the addition of autologous CTG or EMD under CAF improves complete root coverage and may be considered the procedure of choice at maxillary anterior and premolar teeth. The adjunctive benefit needs to be put in the context of increased morbidity of the donor area or increased cost. Additional research is needed to: (i) assess the role of alternatives to autologous soft-tissue grafting in combination with CAF; (ii) identify the optimal surgical design and the need for additional soft-tissue grafting (or alternatives) at multiple recessions, recessions with inter-dental attachment loss and soft-tissue deficiencies at implants.

  • 310. Tonetti, Maurizio S
    et al.
    Van Dyke, Thomas E
    Beck, James
    Bouchard, Philippe
    Cutler, Chris
    D’Aiuto, Francesco
    Dietrich, Thomas
    Eke, Paul
    Graziani, Filippo
    Gunsolley, John
    Herrera, David
    Hart, Thomas
    Shearer, Barbara
    Jepsen, Søren
    Kantarci, Alpdogan
    Loos, Bruno G.
    Progulske-Fox, Ann
    Schenkein, Harvey
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap.
    Tonetti, Maurizio
    Van Dyke, Thomas
    Williams, Ray
    Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases2013Ingår i: Journal of periodontology, ISSN 1943-3670, Vol. 84, nr 4 Suppl, s. S24-S29Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: This consensus report is concerned with the association between periodontitis and atherosclerotic cardiovascular disease (ACVD). Periodontitis is a chronic multifactorial inflammatory disease caused by microorganisms and characterized by progressive destruction of the tooth supporting apparatus leading to tooth loss; as such, it is a major public health issue.

    AIMS: This report examined biological plausibility, epidemiology and early results from intervention trials. PLAUSIBILITY: Periodontitis leads to entry of bacteria in the blood stream. The bacteria activate the host inflammatory response by multiple mechanisms. The host immune response favors atheroma formation, maturation and exacerbation. Epidemiology: In longitudinal studies assessing incident cardiovascular events, statistically significant excess risk for ACVD was reported in individuals with periodontitis. This was independent of established cardiovascular risk factors. The amount of the adjusted excess risk varies by type of cardiovascular outcome and across populations by age and gender. Given the high prevalence of periodontitis, even low to moderate excess risk is important from a public health perspective. Intervention: There is moderate evidence that periodontal treatment: (i) reduces systemic inflammation as evidenced by reduction in C-reactive protein (CRP) and improvement of both clinical and surrogate measures of endothelial function; but (ii) there is no effect on lipid profiles--supporting specificity. Limited evidence shows improvements in coagulation, biomarkers of endothelial cell activation, arterial blood pressure and subclinical atherosclerosis after periodontal therapy. The available evidence is consistent and speaks for a contributory role of periodontitis to ACVD. There are no periodontal intervention studies on primary ACVD prevention and there is only one feasibility study on secondary ACVD prevention.

    CONCLUSIONS: It was concluded that: (i) there is consistent and strong epidemiologic evidence that periodontitis imparts increased risk for future cardiovascular disease; and (ii) while in vitro, animal and clinical studies do support the interaction and biological mechanism, intervention trials to date are not adequate to draw further conclusions. Well-designed intervention trials on the impact of periodontal treatment on prevention of ACVD hard clinical outcomes are needed.

  • 311. Tonetti, Maurizio S
    et al.
    Van Dyke, Thomas E
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases.2013Ingår i: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 40 Suppl 14, s. S24-9Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: This consensus report is concerned with the association between periodontitis and atherosclerotic cardiovascular disease (ACVD). Periodontitis is a chronic multifactorial inflammatory disease caused by microorganisms and characterized by progressive destruction of the tooth supporting apparatus leading to tooth loss; as such, it is a major public health issue.

    AIMS: This report examined biological plausibility, epidemiology and early results from intervention trials. PLAUSIBILITY: Periodontitis leads to entry of bacteria in the blood stream. The bacteria activate the host inflammatory response by multiple mechanisms. The host immune response favors atheroma formation, maturation and exacerbation.

    EPIDEMIOLOGY: In longitudinal studies assessing incident cardiovascular events, statistically significant excess risk for ACVD was reported in individuals with periodontitis. This was independent of established cardiovascular risk factors. The amount of the adjusted excess risk varies by type of cardiovascular outcome and across populations by age and gender. Given the high prevalence of periodontitis, even low to moderate excess risk is important from a public health perspective.

    INTERVENTION: There is moderate evidence that periodontal treatment: (i) reduces systemic inflammation as evidenced by reduction in C-reactive protein (CRP) and improvement of both clinical and surrogate measures of endothelial function; but (ii) there is no effect on lipid profiles - supporting specificity. Limited evidence shows improvements in coagulation, biomarkers of endothelial cell activation, arterial blood pressure and subclinical atherosclerosis after periodontal therapy. The available evidence is consistent and speaks for a contributory role of periodontitis to ACVD. There are no periodontal intervention studies on primary ACVD prevention and there is only one feasibility study on secondary ACVD prevention.

    CONCLUSIONS: It was concluded that: (i) there is consistent and strong epidemiologic evidence that periodontitis imparts increased risk for future cardiovascular disease; and (ii) while in vitro, animal and clinical studies do support the interaction and biological mechanism, intervention trials to date are not adequate to draw further conclusions. Well-designed intervention trials on the impact of periodontal treatment on prevention of ACVD hard clinical outcomes are needed.

  • 312.
    Van de Velde, Tommie
    et al.
    University of Ghent, Belgium.
    Thevissen, Eric
    University of Ghent, Belgium.
    Persson, G. Rutger
    University of Berne, Berne, Switzerland, and the University of Washington, Seattle WA, USA.
    Johansson, Carina
    Örebro University.
    De Bruyn, Hugo
    University of Ghent, Belgium & University of Ghent, Belgium & Malmö University, Malmö, Sweden.
    Two-year outcome with Nobel Direct implants: a retrospective radiographic and microbiologic study in 10 patients.2009Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 11, nr 3, s. 183-193Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    INTRODUCTION: The Nobel Direct implant (Nobel Biocare AB, Göteborg, Sweden) was developed to minimize marginal bone resorption and to result in "soft tissue integration" for an optimized aesthetic outcome. However, conflicting results have been presented in the literature. The aim of this present study was to evaluate the clinical and microbiologic outcomes of Nobel Direct implants.

    MATERIALS AND METHODS: Ten partially edentulous subjects without evidence of active periodontitis (mean age 55 years) received 12 Nobel Direct implants. Implants were loaded with single crowns after a healing period of 3 to 6 months. Treatment outcomes were assessed at month 24. Routine clinical assessments, intraoral radiographs, and microbiologic samplings were made. Histologic analysis of one failing implant and chemical spectroscopy around three unused implants was performed. Paired Wilcoxon signed-rank test was used for the evaluation of bone loss; otherwise, descriptive analysis was performed.

    RESULTS: Implants were functionally loaded after 3 to 6 months. At 2 years, the mean bone loss of remaining implants was 2.0 mm (SD +/- 1.1 mm; range: 0.0-3.4 mm). Three out of 12 implants with an early mean bone loss >3 mm were lost. The surviving implants showed increasing bone loss between 6 and 24 months (p = .028). Only 3 out of the 12 implants were considered successful and showed bone loss of <1.7 mm after 2 years. High rates of pathogens, including Aggregatibacter actinomycetemcomitans, Fusobacterium spp., Porphyromonas gingivalis, Pseudomonas aeruginosa, and Tanerella forsythia, were found. Chemical spectroscopy revealed, despite the normal signals from Ti, O, and C, also peaks of P, F, S, N, and Ca. A normal histologic image of osseointegration was observed in the apical part of the retrieved implant.

    CONCLUSION: Radiographic evidence and 25% implant failures are indications of a low success rate. High counts and prevalence of significant pathogens were found at surviving implants. Although extensive bone loss had occurred in the coronal part, the apical portion of the implant showed some bone to implant integration.

  • 313. Van der Weijden, G A
    et al.
    van Bemmel, K M
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap.
    Implant therapy in partially edentulous, periodontally compromised patients: a review2005Ingår i: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 32, nr 5, s. 506-511Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    AIM: The purpose of the present study was to perform a review using a systematic approach to evaluate the long-term (>/=5 years) success of implants placed in partially edentulous patients with a history of periodontitis as evidenced by loss of supporting bone and implant loss.

    MATERIAL & METHODS: An electronic search of the National Library of Medicine, Washington DC (Medline-PubMed) was performed using specific search terms to identify studies assessing, in periodontitis patients, the success of implants with regard to bone level outcomes. Search was performed on abstracts registered up to October 2003.

    RESULTS: The searches identified 877 abstracts. Titles and abstracts were independently screened by two reviewers (G.A.W. & K.M.B.) to identify publications that met the inclusion criteria. Review of these abstracts resulted in 13 publications for detailed review. These papers were reviewed by the three authors. Finally four papers which met the criteria of eligibility were independently selected by the three reviewers.

    CONCLUSION: Based on the limited data, it seems justified to conclude that the outcome of implant therapy in periodontitis patients may be different compared to individuals without such a history as evidenced by loss of supporting bone and implant loss.

  • 314. Vitaliano, Peter P
    et al.
    Persson, G. Rutger
    University of Washington, Seattle, Washington.
    Kiyak, Asuman
    Saini, Hardeep
    Echeverria, Diana
    Caregiving and gingival symptom reports: psychophysiologic mediators.2005Ingår i: Psychosomatic Medicine, ISSN 0033-3174, E-ISSN 1534-7796, Vol. 67, nr 6, s. 930-938Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVE: We first assessed the association of caregiving with gingival symptom reports. We then assessed whether the observed relationship was mediated by psychophysiologic host factors.

    METHODS: Caregivers of spouses with Alzheimer's disease (n = 123) were compared with demographically similar noncaregiver spouses (n = 117).

    RESULTS: The percentage of caregivers (17%) who reported gingival symptoms was twice that of noncaregivers (8.5%) (p < .05), despite the fact that caregivers and noncaregivers did not differ in oral health care. The relationship between caregiving and gingival symptom reports was mediated by psychophysiologic variables. Caregivers were higher on hassles (p < .05), depressed mood (p < .05), and metabolic risk (insulin, glucose, obesity; p < .05) than were noncaregivers. Greater gingival symptom reports were also associated with greater hassles (p < .01), depressed mood (p < .001), and metabolic risk (p < .001). Measures of subcutaneous fat, inflammation, and frank diabetes were related to gingival symptom reports but not to caregiver status.

    CONCLUSIONS: A higher percentage of caregivers reported gingival symptoms than noncaregivers. These results have implications for research on aging, psychophysiology, and chronic stress.

  • 315.
    Wallin Bengtsson, Viveca
    et al.
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    Persson, G. Rutger
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    Berglund, Johan
    Institute of Technology, Karlskrona.
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    A cross-sectional study of the associations between periodontitis and carotid arterial calcifications in an elderly population2015Ingår i: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 74, nr 2, s. 115-120Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVE: To evaluate if the presence of periodontitis is associated with carotid arterial calcifications diagnosed on panoramic radiographs in an elderly population.

    MATERIALS AND METHODS: Study individuals were randomly selected from the Swedish civil registration database representing the aging population (60-96 years) in Karlskrona, Sweden. Bleeding on probing (BOP) and the deepest probing measurement at each tooth were registered. The proportions of teeth with a probing depth ≥5 mm and the proportion of teeth with bleeding on probing were calculated. Analog panoramic radiographs were taken and the proportion of sites with a distance ≥5 mm between the alveolar bone level and the cement-enamel junction (CEJ) were assessed. A diagnosis of periodontitis was declared if a distance between the alveolar bone level and the CEJ ≥5 mm could be identified from the panoramic radiographs at >10% of sites, probing depth of ≥5 mm at one tooth or more and with BOP at >20% of teeth.

    RESULTS: Readable radiographs were obtained from 499 individuals. Carotid calcification was identified in 39.1%. Individuals were diagnosed with periodontitis in 18.4%. Data analysis demonstrated that individuals with periodontitis had a higher prevalence of carotid calcifications (Pearson χ (2) = 4.05 p < 0.05) and with a likelihood of 1.5 (95% CI = 1.0, 2.3, p < 0.05).

    CONCLUSIONS: Data analysis demonstrated a significant association between periodontitis and carotid calcification.

  • 316.
    Wallin Bengtsson, Viveca
    et al.
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III.
    Persson, G. Rutger
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet.
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet.
    Assessment of carotid calcifications on panoramic radiographs in relation to other used methods and relationship to periodontitis and stroke: a literature review2014Ingår i: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 72, nr 6, s. 401-412Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Objectives. To assess the literature on carotid calcifications defined from panoramic radiographs (PMX) and concurrent diagnosis of stroke and periodontitis.

    Materials and methods. A literature search screening for publications using search terms such as PMX and carotid calcification, stroke and periodontitis was performed in November 2012.

    Results. A total of 189 articles were retrieved, among which 30 were included in the review. The sensitivity for PMX findings of carotid calcifications (CC) compared to a diagnosis by Doppler sonography varied between 31.1–100%. The specificity for PMX findings of carotid calcifications compared to a diagnosis by Doppler sonography varied between 21.4–87.5%. Individuals with CC findings from PMX have more periodontitis and risk for stroke.

    Conclusions. There is a shortage of well-designed studies in older dentate individuals assessing the associations between periodontitis and radiographic evidence of CC and in relation to stroke or other cardiovascular diseases.

    Statement of Clinical Relevance. Carotid calcifications are prevalent in patients with periodontitis and such individuals may have an increased risk for stroke. The absence of signs of carotid calcification on panoramic radiographs is indicative of no calcification of carotid arteries.

  • 317.
    Wallin Bengtsson, Viveca
    et al.
    Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL). Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för oral hälsa.
    Persson, Rutger G
    Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL). Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för oral hälsa. USA.
    Berglund, Johan
    Institute of Technology.
    Renvert, Stefan
    Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL). Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för oral hälsa.
    Carotid calcifications in panoramic radiographs are associated with future stroke or ischemic heart diseases: a long-term follow-up study2019Ingår i: Clinical Oral Investigations, ISSN 1432-6981, E-ISSN 1436-3771, Vol. 23, nr 3, s. 1171-1179Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVE: To assess if carotid calcifications detected in panoramic radiographs are associated with future events of stroke, and/or ischemic heart diseases over 10-13 years in individuals between 60 and 96 years.

    MATERIALS AND METHODS: Baseline (2001-2004) panoramic radiographs were assessed for evidence of carotid calcifications from individuals with no previous history of stroke and/or ischemic heart diseases. A radiopaque nodular mass adjacent to the cervical vertebrae, at or below the intervertebral space C3-C4, was interpreted as carotid calcification. Annual medical records were searched for ICD 10 codes through 2014.

    RESULTS: Signs of carotid calcification was demonstrated in 238/635 (37.5%) of the study individuals. Signs of carotid calcification was associated with future stroke and/or ischemic heart diseases (χ2 = 9.1, OR 1.6, 95% CI 1.2, 2.2, p < 0.002). In individuals 60-72 years, a significant association between radiographic signs of carotid calcification and stroke and/or ischemic heart diseases (χ2 = 12.4, OR 2.4, 95% CI 1.5, 4.0, p < 0.000) (adjusted for high blood pressure, diabetes type 2, BMI; OR 1.9, 95% CI 1.1, 3.5, p = 0.03). Individuals (60-72 years) with radiographic evidence of carotid calcifications had a mean cumulative stroke and/or ischemic heart diseases survival time of 12.1 years compared to those without such evidence (13.0 years) (log rank Mantel-Cox χ2 = 10.7, p = 0.001).

    CONCLUSIONS: Evidence of carotid calcifications in panoramic radiographs is associated with an event of stroke and/or ischemic heart diseases in 60-96-year-old individuals.

    CLINICAL RELEVANCE: Radiographic evidence of carotid calcifications is associated with stroke and/or ischemic heart diseases. Patients with signs of carotid calcifications should therefore be referred for medical examination.

  • 318.
    Wang, Chin-Wei
    et al.
    USA.
    Renvert, Stefan
    Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL). Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för oral hälsa.
    Wang, Hom-Lay,
    USA.
    Nonsurgical treatment of periimplantitis2019Ingår i: Implant Dentistry, ISSN 1056-6163, E-ISSN 1538-2982, Vol. 28, nr 2, s. 155-160Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: Periimplantitis has become an emerging challenge faced by practicing dentists worldwide. When treating periimplantitis, we should attempt to manage this problem via nonsurgical therapies that include addressing all modifiable systemic risk factors and local contributing factors. Hence, the aim of this narrative review was to examine published studies on nonsurgical treatment of periimplantitis and evaluate their effectiveness and limitations.

    Materials and Methods: A literature search was performed in MEDLINE via PubMed database up to December 31, 2017. Current published clinical approaches focused on mechanical debridement, adjunctive antiseptictherapy, adjunctive antibiotic therapy, laser-assisted therapy, and combination approaches were included in this analysis.

    Results: Nonsurgical therapy of periimplantitis may result in complete healing of the disease and the patient is then placed on a supportive maintenance program. If the disease is not resolved and surgical intervention is not an option, active nonsurgical retreatment may be considered. In many cases where disease is not resolved, surgical therapy or implant removal could be considered.

    Conclusions: Nonsurgical treatment of periimplantitis usually provides clinical improvements in reducing bleeding tendency and in some cases pocket reduction. Early diagnosis, detection, and intervention remain the key for managing periimplantitis.

  • 319.
    Wayele, Ban
    et al.
    Högskolan Kristianstad, Sektionen för hälsa och samhälle.
    Nezami, Rashida
    Högskolan Kristianstad, Sektionen för hälsa och samhälle.
    Förekomst av parodontit och karies hos typ 2 – diabetiker2012Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
    Abstract [en]

    The aim of this study was to describe the prevalence of gingivitis, periodontitis and dental caries in individuals with type 2 – diabetes. The study was conducted in a form of a general literature review with the restricted to the following conditions: human studies, English, and articles published between 2007 - 2012. Articles lacking a control group were excluded. The data were collected through searches of the medical database PubMed. A compilation of 11 scientific articles was examined.

    In individuals with diabetes mellitus type 2, the presence of gingivitis was identified in 3 articles, periodontitis in 10, and dental caries in 3 articles. The 3 articles that showed presence of gingivitis demonstrated that individuals with type 2 – diabetes had a higher prevalence of gingivitis compared to non-diabetic individuals. A higher prevalence of periodontitis in individuals with type 2 – diabetes mellitus was found in 10/10 publications. Theses studies demonstrated in individuals with type 2 – a significantly higher incidence of deep pocket depths, attachment loss, recession defects and with higher plaque and gingival index scores. The three articles that showed the presence of dental caries also demonstrated a higher prevalence of dental caries in individuals with type 2 – diabetes mellitus. 

    The articles included in the literature study showed statistically significant higher prevalence of gingivitis, periodontitis, and dental caries in individuals with type 2 – diabetes mellitus than in individuals without a diagnosis of diabetes.

    Keywords: Type 2 – Diabetes, Gingivitis, Periodontitis and Dental Caries

  • 320. Widenheim, Jan
    et al.
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap.
    Birkhed, Dowen
    Förebyggande tandvård1997 (uppl. 1)Bok (Övrigt vetenskapligt)
  • 321. Widenheim, Jan
    et al.
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap.
    Birkhed, Dowen
    Förebyggande tandvård2003 (uppl. 2)Bok (Övrigt vetenskapligt)
  • 322.
    Widén, Cecilia
    et al.
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III.
    Coleman, Michael
    Storbritannien.
    Critén, Sladjana
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III.
    Karlgren-Andersson, Pernilla
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III.
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III. Blekinge Institute of Technology & Trinity College, Dublin .
    Persson, G Rutger
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III. USA.
    Consumption of bilberries controls gingival inflammation2015Ingår i: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 16, nr 5, s. 10665-73Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Bioactive molecules in berries may be helpful in reducing the risk of oral diseases. The aim of this study was to determine the effect of bilberry consumption on the outcome of a routine dental clinical parameter of inflammation, bleeding on probing (BOP), as well as the impact on selected biomarkers of inflammation, such as cytokines, in gingival crevicular fluid (GCF) in individuals with gingivitis. Study individuals who did not receive standard of care treatment were allocated to either a placebo group or to groups that consumed either 250 or 500 g bilberries daily over seven days. The placebo group consumed an inactive product (starch). A study group, receiving standard of care (debridement only) was also included to provide a reference to standard of care treatment outcome. Cytokine levels were assayed using the Luminex MagPix system. The mean reduction in BOP before and after consumption of test product over 1 week was 41% and 59% in the groups that consumed either 250 or 500 g of bilberries/day respectively, and was 31% in the placebo group, and 58% in the standard of care reference group. The analysis only showed a significant reduction in cytokine levels in the group that consumed 500 g of bilberries/day. A statistically significant reduction was observed for IL-1b (p = 0.025), IL-6 (p = 0.012) and VEGF (p = 0.017) in GCF samples in the group that consumed 500 g of bilberries daily. It appears that berry intake has an ameliorating effect on some markers of gingival inflammation reducing gingivitis to a similar extent compared to standard of care.

  • 323.
    Widén, Cecilia
    et al.
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    Critén, Sladjana
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    Persson, Rutger G
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    Measuring inflammatory markers in saliva in polyphenols research2016Ingår i: 29th International Horticultural Congress on Horticulture: Sustaining Lives, Livelihoods and Landscapes (IHC) / [ed] Finn, CE & Mezzetti, B, 2016, s. 201-206Konferensbidrag (Refereegranskat)
    Abstract [en]

    There is currently an interest in the possible anti-inflammatory effects of intake of fruits and berries. The aim of this study was to determine whether the twice daily administration of a berry beverage rich in polyphenols had effects on salivary levels of a selected group of pro-inflammatory cytokines for one week in a pre-and post-study design. Levels of selected cytokines were compared in whole saliva and saliva obtained using commercially available collection devices (Salivette (R) Cotton and Salivette (R) Synthetic rolls). Twenty healthy subjects drank 200 mL of a berry beverage consisting of equal parts of bilberries (Vaccinium myrtillus), black currant (Ribes nigrum), lingonberries (Vaccinium vitis-idaea), sea buckthorn (Hippophae rhamnoides) diluted with 50% water. Levels of cytokines, IL-1 beta, IL-8, IL-12 and TNF-alpha were assessed. Levels of cytokines differed between sources of collection but were highest in whole saliva. The use of cotton or synthetic rolls does not seem to be useful as a method for saliva collection and cytokine analysis. There was no significant change in the levels of selected cytokines at baseline and after intake of the berry beverage in whole stimulated saliva. There was a large inter-individual variation in cytokine levels.

  • 324.
    Widén, Cecilia
    et al.
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap.
    Holmer, Helene
    Kristianstad Central Hospital, Kristianstad.
    Coleman, Michael
    England.
    Tudor, Marian
    Kristianstad Central Hospital, Kristianstad.
    Ohlsson, Ola
    Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL). Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap.
    Sättlin, Susanna
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap.
    Persson, G Rutger
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).
    Systemic inflammatory impact of periodontitis on acute coronary syndrome2016Ingår i: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 43, nr 9, s. 713-719Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    AIM: A causative relationship between acute coronary syndrome (ACS) and periodontitis has yet to be defined. The aim of this study was to assess differences in levels of serum cytokines between individuals with or without ACS or periodontal comorbidity.

    MATERIAL AND METHODS: In a case-control study, individuals with ACS (78 individuals, 10.3% females) and matching healthy controls (78 individuals, 28.2% females) were included. Medical and dental examinations were performed to diagnose ACS and periodontitis. Serum levels of cytokines were assessed using Luminex technology.

    RESULTS: A diagnosis of periodontitis in the ACS and control group was diagnosed in 52.6% and 12.8% of the individuals, respectively. The unadjusted odds-ratio that individuals with ACS also had periodontitis was 7.5 (95% CI: 3.4, 16.8, p<0.001). Independent of periodontal conditions, individuals with ACS had significantly higher serum levels of IL8 (mean: 44.3 and 40.0 pg/ml) and vascular endothelial growth factor (VEGF) (mean: 82.3 and 55.3 pg/ml) than control individuals. A diagnosis of periodontitis made no difference in serum cytokine expressions.

    CONCLUSION: Elevated serum levels of VEGF were associated with ACS. Serum cytokine expression in individuals with ACS is unrelated to periodontal conditions. This article is protected by copyright. All rights reserved.

  • 325.
    Widén, Cecilia
    et al.
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III.
    Renvert, Stefan
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet.
    Persson, G. Rutger
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen Oral hälsa.
    Antibacterial activity of berry juices, an in vitro study2015Ingår i: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 73, nr 7, s. 539-543Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective

    The aim of the present study was to evaluate in vitro antibacterial activities of blackcurrant and sea buckthorn juices on bacteria associated with gingival inflammation.

    Materials and methods

    The growth of selected bacteria (Streptococcus mitis, Streptococcus mutans, Streptococcus sanguinis, Streptococcus gordonii, Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa) was studied in vitro on agar plates. The content of phenols in the different extracts was measured with HPLC-ESI-MS.

    Results

    The spectrometric analysis identified that the highest level of the single phenols studied was found for ferulic acid (113 μg/ml) in blackcurrant juice. Sea buckthorn contained low levels of selected phenols. Total bacterial inhibition for all bacterial species studied was found at 20% berry juice concentration with pH varying between 4.1-5.4.

    Conclusions

    The present study identified that in vitro bacterial growth on agar plates was inhibited by blackcurrant and sea buckthorn juices and that low juice pH explains bacterial in vitro growth. This may have clinical implications in biofilm development, reducing the risks for both tooth decay and gingivitis.

  • 326. Wyatt, C C L
    et al.
    Maupome, G
    Hujoel, P P
    MacEntee, M I
    Persson, G. Rutger
    University of Bern, Bern, Switzerland & University of Washington, Seattle, WA, USA.
    Persson, Rigmor E.
    Kiyak, H A
    Chlorhexidine and preservation of sound tooth structure in older adults: A placebo-controlled trial2007Ingår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 41, nr 2, s. 93-101Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The Trial to Enhance Elderly Teeth Health (TEETH) was designed to test the impact of regular rinsing with a 0.12% chlorhexidine (CHX) solution on tooth loss, and the causes of tooth loss (caries, periodontal disease and trauma) were also investigated. This paper reports on the effectiveness of a 0.12% CHX solution for controlling caries using a tooth surface (coronal and root) survival analysis. A total of 1,101 low income elders in Seattle (United States) and Vancouver (Canada), aged 60-75 years, were recruited for a double-blind clinical trial and assigned to either a CHX (n = 550) or a placebo (n = 551) mouth rinse. Subjects alternated between daily rinsing for 1 month, followed by weekly rinsing for 5 months. All sound coronal and root surfaces at baseline were followed annually for up to 5 years. At each follow-up examination, those tooth surfaces with caries, restored, or extracted were scored as 'carious'. The hazard ratio associated with CHX for a sound surface to become filled, decayed, or extracted was 0.87 for coronal surfaces (95% confidence interval: 0.71-1.14, p = 0.20) and 0.91 for root surfaces (95% confidence interval: 0.73-1.14, p = 0.41). These findings suggest that regular rinsing with CHX does not have a substantial effect on the preservation of sound tooth structure in older adults.

  • 327.
    Zeigler, Cecilia C
    et al.
    Karolinska Institutet, Stockholm, Sweden.
    Persson, G. Rutger
    University of Berne, Berne, Switzerland & University of Washington, Seattle, Washington, USA.
    Wondimu, Biniyam
    Karolinska Institutet, Stockholm, Sweden.
    Marcus, Claude
    Karolinska Institutet, Stockholm, Sweden.
    Sobko, Tanja
    Karolinska Institutet, Stockholm, Sweden.
    Modéer, Thomas
    Karolinska Institutet, Stockholm, Sweden.
    Microbiota in the oral subgingival biofilm is associated with obesity in adolescence.2012Ingår i: Obesity (Silver Spring, Md.), ISSN 1930-739X, Vol. 20, nr 1, s. 157-164Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    To test the hypothesis whether microbiota in oral biofilm is linked with obesity in adolescents we designed this cross-sectional study. Obese adolescents (n = 29) with a mean age of 14.7 years and normal weight subjects (n = 58) matched by age and gender were examined with respect to visible plaque index (VPI%) and gingival inflammation (bleeding on probing (BOP%)). Stimulated saliva was collected. They answered a questionnaire concerning medical history, medication, oral hygiene habits, smoking habits, and sociodemographic background. Microbiological samples taken from the gingival crevice was analyzed by checkerboard DNA-DNA hybridization technique. The sum of bacterial cells in subgingival biofilm was significantly associated with obesity (P < 0.001). The link between sum of bacterial cells and obesity was not confounded by any of the studied variables (chronic disease, medication, VPI%, BOP%, flow rate of whole saliva, or meal frequency). Totally 23 bacterial species were present in approximately threefold higher amounts, on average, in obese subjects compared with normal weight controls. Of the Proteobacteria phylum, Campylobacter rectus and Neisseria mucosa were present in sixfold higher amounts among obese subjects. The association between obesity and sum of bacterial cells in oral subgingival biofilm indicates a possible link between oral microbiota and obesity in adolescents.

  • 328.
    Åsen, Kristina
    et al.
    Högskolan Kristianstad, Sektionen för Hälsa och Samhälle.
    Boking, Anna
    Högskolan Kristianstad, Sektionen för Hälsa och Samhälle.
    Dental erosion: kolsyrade vattens erosiva potential2009Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Syftet med studien var att undersöka den erosiva potentialen av vanligt förekommande kolsyrade vatten med eller utan smaksättning. Studien genomfördes som en laboratoriestudie vid Institutionen för Odontologi vid Göteborgs universitet. Totalt omfattades studien av 34 buteljerade kolsyrade vatten med eller utan smak, tre kolsyrade vatten producerade i kolsyreapparat samt sex referensdrycker. Samtliga produkter testades genom registrering av initialt pH med pH-elektrod och buffring med 0,1 M NaOH till det värde då pH neutraliserats. Dryckens surhetsgrad beräknades därefter vilket anses som ett mått på dess erosiva potential. Resultatet visade att majoriteten av kolsyrade vatten hade ett initialt pH-värde >5 men variationer fanns mellan varumärken. Samtliga studerade vatten uppvisade en lägre erosiv potential jämfört med referensdrycker som färskpressad citron- och apelsinjuice, men inte jämfört med läskedrycker. Data visade att syrakoncentrationen steg när mängden kolsyra ökade. Olika smaktillsatser hade endast en mindre påverkan på den erosiva potentialen. Denna studie visade att kolsyremängden var av större betydelse än smaktillsats för syrakoncentrationen i vattnet.

  • 329.
    Östberg, Anna-Lena
    et al.
    Karlstad University.
    Andersson, Pia
    Högskolan Kristianstad, Sektionen för hälsa och samhälle.
    Hakeberg, Magnus
    Jönköping University.
    Cross-cultural adaptation and validation of the Oral Impacts on Daily Performances OIDP) in Swedish2008Ingår i: Swedish Dental Journal, ISSN 0347-9994, Vol. 32, nr 4, s. 187-195Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVES: The aim was to assess the validity and reliability of a Swedish version of the Oral impacts on Daily Performance (OIDP) index measuring oral health-related quality of life. MATERIAL AND METHODS: After translation and cultural adaptation, a 3-site sample of 204 adults (20-86 years) was interviewed using the OIDP. Moreover, the study included a self-administered questionnaire and a clinical examination. RESULTS: A total of 39.7% reported at least one oral impact on daily life. The most common performances affected were eating and cleaning teeth (both 20.6%). Oral effects on psychological performances caused the highest impacts. No gender or age differences were demonstrated with respect to having at least one impact. However, among those affected, women, old and young subjects scored higher than men and other ages, respectively, on the OIDP. The face and content validity were deemed good in pilot interviews with laypersons and dental professionals. The construct validity was confirmed, as the OIDP score was consistently associated with self-perceived oral health OR 2.13 (95% CI 1.10-4.10) and other self-rated variables, e.g. satisfaction with oral health OR 2.43 (CI 1.34-4.41), also when accounting for age, gender and socioeconomic differences. Associations were estimated using logistic regression. Lacking 10 or more teeth was associated with a higher OIDP score, which supports the criterion validity of the instrument. In a test-retest analysis Cohen's kappa was 0.77. CONCLUSIONS: The Swedish version of the OIDP appears to be a valid and reliable measure for assessing oral impacts on daily performances.

  • 330.
    Östberg, Anna-Lena
    et al.
    Karlstad University.
    Andersson, Pia
    Högskolan Kristianstad, Sektionen för hälsa och samhälle.
    Hakeberg, Magnus
    Jönköping University.
    Oral impacts on daily performances: associations with self-reported general health and medication2009Ingår i: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 67, nr 6, s. 370-376Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective. The aim of the present study was to examine the impact of general diseases and medication on oral health-related quality of life (OHRQoL) in a Swedish adult population using the Swedish version of Oral Impacts on Daily Performances (OIDP). Material and methods. A three-site sample of 200 adults (20-86 years; participation rate 70%) was interviewed using the OIDP, and a medical anamnesis was performed in 2006-7. A self-reported questionnaire provided complementary socio-economic data. Results. The burden of medical diagnoses and medications was greatest among the older participants in the study. The mean number of medicines in regular users was: ≥60 years, 3.6 (SD 2.6); 40-59 years, 1.9 (SD 1.5); and 20-40 years, 1.9 (SD 1.8) (p =0.013). There were no gender differences in general health or medication variables. Self-reported health, medical diagnoses and medication were significantly and consistently associated with the OIDP score: subjects with ≥1 diagnosis, OR 2.22 (95% CI 1.19-4.14) and subjects with ≥1 medicines, OR 1.85 (95% CI 1.01-3.40) versus those without diagnoses or medication. However, there was a clear gradient: OIDP scores increased with increasing numbers of diagnoses and medicines. Conclusion. The Swedish version of the OIDP was found useful for measuring impacts of general health and medication on OHRQoL. Dental care should pay special attention to patients with medical conditions or who are on medication, because these patients are more likely to experience oral impacts on daily performances.

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