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  • 1.
    Andersson, Camilla
    et al.
    Högskolan Kristianstad, Sektionen för hälsa och samhälle.
    Andersson, Kristina
    Högskolan Kristianstad, Sektionen för hälsa och samhälle.
    Existentiell smärta hos patienter med cancer i palliativt skede2011Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Smärta i livets slutskede behöver inte bara innebära det fysiska obehaget, utan kan även ha psykiska, sociala och existentiella dimensioner. Existentiell smärta har en stor plats i den palliativa vården, kropp och själ hör ihop. Tankar kring livets mening, skuld och vad som händer efter döden kan ge existentiell smärta. De existentiella behoven är enligt många studier försummade. Vårdpersonal undviker ofta dessa frågor.Syftet med studien var att beskriva existentiell smärta hos patienter med cancer i palliativt skede. Metod: En allmänlitteraturstudie genomfördes med kvalitativa artiklar. Resultatet visade att existentiell smärta förekom i stor omfattning. Informanterna upplevde ensamhet och skuldkänslor och smärtan beskrevs ofta i fysiska termer. Smärtan hade också samband med förlust av olika funktioner. Det fanns även tankar kring andlighet och rädsla för den okända framtiden.Diskussion: Det är viktigt att sjuksköterskan är uppmärksam på patientens behov av närhet eller ensamma stunder. Vårdpersonal kan även hjälpa patienten att återfinna sin autonomi genom att identifiera de funktioner som faktiskt finns kvar. Genom samtal kan patienten få stöd att orka leva de sista dagarna samt att möta den okända framtiden. Slutsatsen är att det krävs god kunskap i kommunikation och smärtbehandling för att kunna identifiera och lindra existentiell smärta.

  • 2.
    Bolejko, Anetta
    et al.
    Skåne University Hospital Malmö.
    Hagell, Peter
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap I. Högskolan Kristianstad, Forskningsmiljön PRO-CARE.
    Wann-Hansson, Christine
    Malmö University.
    Zackrisson, Sophia
    Skåne University Hospital Malmö.
    Prevalence, long-term development, and predictors of psychosocial consequences of false-positive mammography among women attending population-based screening2015Inngår i: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 24, nr 9, 1388-97 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Cancer screening aims to detect cancer at an asymptomatic stage, although side effects from screening also occur. We investigated the prevalence, longitudinal development, and predictors of psychosocial consequences of false-positive breast cancer screening.

    METHODS: Three hundred ninety-nine women with false-positive screening mammography responded to the Consequences of Screening-Breast Cancer (COS-BC) questionnaire immediately after a negative diagnosis (free from breast cancer) following recall examination(s) (baseline), and 6 and 12 months later. Age-matched controls (n = 499) with a negative mammogram responded to the COS-BC at the same occasions. Five COS-BC scales (Sense of dejection, Anxiety, Behavioral, Sleep, and Existential values) were used as outcome measures.

    RESULTS: Women with false-positive mammography had consistently higher prevalence of all five consequences compared with controls (P < 0.001). The prevalences decreased between baseline and 6 months (P < 0.001) but were stable between 6 and 12 months (P ≥ 0.136). Early recall profoundly predicted long-term consequences for all five outcomes (OR, 3.05-10.31), along with dissatisfaction with information at recall (OR, 2.28-2.56), being foreign-born (OR, 2.35-3.71), and lack of social support (OR, 1.13-1.25).

    CONCLUSION: This 1-year longitudinal study shows that women experience psychosocial consequences of false-positive screening mammography. Early recall should be performed cautiously, and provision of information as well as social support may reduce psychosocial consequences.

    IMPACT: Although delivery of population-based screening reduces breast cancer mortality, it also raises the issue of its impact on the psychosocial well-being of healthy women. Our findings identify predictors that can be targeted in future efforts to reduce the side effects of mammographic screening.

  • 3.
    Emilsson, Mimmi
    et al.
    Högskolan Kristianstad, Sektionen för hälsa och samhälle.
    Hansson, Johanna
    Högskolan Kristianstad, Sektionen för hälsa och samhälle.
    Mötet mellan patienter med cancer och sjuksköterskan: en litteraturstudie om patienters upplevelser2015Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Bakgrund: När en person drabbas av cancer förändras hela ens livsvärld. Bristande kunskap ger en känsla av att inte få grepp om situationen och därför är det viktigt att sjuksköterskan ger en god omvårdnad med fokus på helhet och kommunikation. Syfte: Syftet med litteraturstudien var att beskriva patienters upplevelser av sjuksköterskans bemötande vid cancerbehandling på sjukhus. Metod: En litteraturstudie som bygger på tio kvalitativa artiklar. Resultat: Genom analys hittades tre huvudkategorier: Vikten av bred kunskap hos sjuksköterskan, Vikten av en bra vårdrelation och Vikten av ett bra omhändertagande som gynnar patientens välbefinnande och viljan att vara delaktig. Metoddiskussion: Att det inte hittades så många artiklar inom ämnet beror på att det mest finns forskning som är ur sjuksköterskans perspektiv. Förförståelsen bekräftades och författarna fick mer insikt i hur viktigt det verkligen är med tvåvägskommunikation. Resultatdiskussion: Patienten vill känna ett intresse från sjuksköterskans sida och en bra relation mellan dessa två uppstår då god kommunikation finns. 

  • 4.
    Fridberg, Marie
    et al.
    Lund University.
    Tassidis, Helena
    Lund University.
    Gjörloff Wingren, Anette
    Malmö University.
    PTPN7 (protein tyrosine phosphatase, nonreceptor type 7)2010Inngår i: Atlas of Genetics and Cytogenetics in Oncology and Haematology, ISSN 0187-6236, E-ISSN 1768-3262, Vol. 14, nr 11, 1032-1033 s.Artikkel i tidsskrift (Annet vitenskapelig)
  • 5.
    Koinberg, Inga-Lill
    et al.
    Högskolan Kristianstad, Sektionen för hälsa och samhälle.
    Engholm, G. B.
    Department of Oncology, University Hospital, Örebro.
    Genell, A.
    Oncological center west health care region, University hospital, Gothenburg.
    Holmberg, L.
    Department of surgical sciences, Uppsala University.
    A health economic evaluation of follow up after breast cancer surgery: result from of an rct study2008Inngår i: European Journal of Cancer Supplements, ISSN 1359-6349, Vol. 6, nr 7, 167- s.Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    Introduction: We studied the costs of following 264 breast cancer patients, stage I and II, randomised to two different follow-up programmes in a prospective trial, involving, on the one hand, routine follow-up visits to the physician with follow-up visits twice a year or more over five years (PG = physician group), and on the other, specialist nurse intervention with check-ups on demand (NG = nurse group). The trial period was 5 years. The women in the two intervention groups did not differ in anxiety and depression, their satisfaction with care, their experienced accessibility to the medical centre or their medical outcome as measured by recurrence or death.

    Patients and Methods: The analyses were done from different lists representing costs at three hospitals in Sweden according to the principles of a cost minimization study. Result: The cost per person year of follow-up differed between the groups, with €630 per person year in PG compared to €495 per person year in NG. Thus, specialist nurse intervention with check-ups on demand was 20% less expensive than routine follow-up visits to the physician. The main difference in cost between the groups was explained by the numbers of visits to the physician in the respective study arms. There were 21% more primary contacts in PG than NG.

    Discussion: The difference in cost per year and patient by study arm is modest, but transforms to nearly €9,000 per patient and 5-year period, offering a substantial opportunity for reallocating resources since breast cancer is the most prevalent tumour worldwide.

  • 6.
    Tassidis, Helena
    et al.
    Lund University.
    Brokken, Leon J. S.
    Lund University.
    Jirström, Karin
    Lund University.
    Ehrnström, Roy
    Lund University.
    Pontén, Fredrik
    Uppsala University.
    Ulmert, David
    Lund University.
    Bjartell, Anders
    Lund University.
    Härkönen, Pirkko
    Lund University.
    Gjörloff Wingren, Anette
    Lund University.
    Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer2010Inngår i: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 126, nr 10, 2296-2307 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The protein tyrosine kinase (PTK) receptors and cytosolic signaling proteins as well as the protein tyrosine phosphatases (PTPs) have important roles in regulation of growth of the benign and malignant prostate gland. Here, we studied expression of the protein tyrosine phosphatase SHP-1 in prostate cancer cell lines and in human prostatic tissues. SHP-1 is expressed at a high level in LNCaP prostate cancer cells compared with PC3 cells. Silencing of SHP-1 expression with siRNA in LNCaP cells led to an increased rate of proliferation, whereas overexpression of SHP-1 by means of transient and stable transfection in PC3 cells led to a decrease in proliferation. Corresponding changes were observed in cyclin D1 expression. We further demonstrate that LNCaP and PC3 cells respond differently to IL-6 stimulation. SHP-1 overexpression in PC3 cells reversed IL-6 stimulation of proliferation, whereas in SHP-1-silenced LNCaP cells, IL-6 inhibition of proliferation was not affected. In addition, IL-6 treatment led to higher levels of phosphorylated STAT3 in SHP-1-silenced LNCaP cells than in control cells. Next, SHP-1 expression in human prostate cancer was analyzed by immunohistochemical staining of tissue microarrays comprising tumor specimens from 100 prostate cancer patients. We found an inverse correlation between the tumor level of SHP-1 expression and time to biochemical recurrence and clinical progression among prostate cancer patients. In conclusion, our results suggest that a decreased level of SHP-1 expression in prostate cancer cells is associated with a high proliferation rate and an increased risk of recurrence or clinical progression after radical prostatectomy for localized prostate cancer.

  • 7.
    Tassidis, Helena
    et al.
    Lund University.
    Brokken, Leon
    Ulmert, David
    Ehrnström, Roy
    Jirström, Karin
    Bjartell, Anders
    Härkönen, Pirkko
    Gjörloff Wingren, Anette
    Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer2009Inngår i: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 69, nr 9 Supplement, LB-257- s.Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    The protein tyrosine kinase (PTK) receptors and cytosolic signalling proteins as well as the protein tyrosine phosphatases (PTP) have important roles in regulation of growth and function of the benign and malignant prostate gland. Here we studied the expression levels and functions of the protein tyrosine phosphatase SHP-1 in prostate cancer cell lines and in benign and malignant human prostatic tissues. We found that SHP-1 is expressed at a high level in LNCaP prostate cancer cells compared to PC-3 cells. Silencing of SHP-1 expression with siRNA in LNCaP cells led to an increased rate of proliferation as measured by thymidine incorporation, whereas in PC3 cells in which SHP1 was overexpressed by transient transfection proliferation rate was decreased. We also examined SHP-1 expression in prostate cancer by immunohistochemical staining of tissue microarrays comprising tumor specimens from 122 prostate cancer patients. We found an inverse correlation between SHP-1 staining intensity and the time to biochemical recurrence as measured by a rise in the serum level of prostate-specific antigen (PSA) in prostate cancer patients. In conclusion, our results suggest that a low level of SHP-1 expression in prostate cancer cells is associated with high proliferation rate and with an increased risk of biochemical recurrence after radical prostatectomy for localized prostate cancer.

  • 8.
    Tassidis, Helena
    et al.
    Lund University.
    Culig, Zoran
    Österrike.
    Gjörloff Wingren, Anette
    Lund University.
    Härkönen, Pirkko
    Lund University.
    Role of the protein tyrosine phosphatase SHP-1 in Interleukin-6 regulation of prostate cancer cells2010Inngår i: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 70, nr 14, 1491-1500 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the modulation of growth and progression of prostate cancer. Decreased expression of the tyrosine phosphatase SHP-1, involved in regulation of cytokine and tyrosine kinase receptor signaling, has been shown to be associated with less favorable outcome among prostate cancer patients.

    METHODS: Parental LNCaP cells and an LNCaP-IL6+ subline, derived from parental LNCaP cells by continuous culture of the cells in the presence of recombinant IL-6 were used in the study. Expression of STAT3, pSTAT3, ERK, pERK, AKT, pAKT, PTEN, and SHP-1 was analyzed by immunohistochemistry, Western blots, cDNA microarray, quantitative PCRs, and reverse transcriptase PCRs. Proliferation and apoptosis of transfected cells were analyzed by caspase3/7 assay and flow cytometry.

    RESULTS: Phosphorylation of ERK and STAT3 was increased in the LNCaP-IL6+ subline compared with LNCaP cells, whereas pAKT was decreased. Overexpression and inhibition experiments with SHP-1 siRNA showed that SHP-1 reduced proliferation and increased apoptosis in both cell lines. Microarray analysis revealed 80 up-regulated and 87 down-regulated SHP-1-related genes in the LNCaP-IL6+ cell line compared with LNCaP cells.

    CONCLUSIONS: SHP-1 suppresses growth and increases apoptosis in both LNCaP and LNCaP-IL6+ cells, which suggests that SHP-1 could be a therapeutic target in prostate cancer, even when there is an IL-6-related growth advantage.

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