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  • 1.
    Hagell, Peter
    Department of Health Sciences, Lund University.
    Nursing and multidisciplinary interventions for Parkinson's disease: what is the evidence?2007In: Parkinsonism & Related Disorders, ISSN 1353-8020, E-ISSN 1873-5126, Vol. 13, no Suppl.3, p. S501-S508Article in journal (Refereed)
    Abstract [en]

    This paper reports the interim results of an ongoing systematic review of the available evidence for the effectiveness of nursing care for people with Parkinson's disease (PD). Five clinical and four health-economic evaluations suggest that the clinical and cost effectiveness of nursing care for PD remain inconclusive. This is in contrast to clinical experience and may be due to issues related to study designs, study interventions, and the outcome measures used. More studies are needed and may benefit from considering specific interventions evaluated using outcome measures that are valid and responsive representations of their expected outcomes.

  • 2.
    Hagell, Peter
    et al.
    Department of Nursing, Lund University.
    McKenna, Stephen P.
    Galen Research, Manchester.
    International use of health status questionnaires in Parkinson's disease: translation is not enough2003In: Parkinsonism & Related Disorders, ISSN 1353-8020, E-ISSN 1873-5126, Vol. 10, no 2, p. 89-92Article in journal (Refereed)
    Abstract [en]

    The present study assessed the linguistic and content validity of the Swedish version of the 39-item Parkinson's disease questionnaire (PDQ-39). The frame question, response alternatives and two of the 39 items yielded substantial linguistic and stylistic problems. Such shortcomings would be expected to influence responses to, and the quality of, the whole questionnaire. Data support content validity of the PDQ-39 as a functional health status questionnaire, although some shortcomings were identified. This preliminary study illustrates the need for documented linguistic validity before new language adaptations of patient-reported outcome measures can be considered suitable for use in clinical trials, research, and practice.

  • 3.
    Hjelmgren, Jonas
    et al.
    The Swedish Institute for Health Economics, Lund.
    Ghatnekar, Ola
    The Swedish Institute for Health Economics, Lund.
    Reimer, Jan
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund.
    Grabowski, Martin
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund.
    Lindvall, Olle
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund.
    Persson, Ulf
    The Swedish Institute for Health Economics, Lund.
    Hagell, Peter
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund.
    Estimating the value of novel interventions for Parkinson's disease: an early decision-making model with application to dopamine cell replacement2006In: Parkinsonism & Related Disorders, ISSN 1353-8020, E-ISSN 1873-5126, Vol. 12, no 7, p. 443-452Article in journal (Refereed)
    Abstract [en]

    A long-term cost-effectiveness model for early decision-making and estimation of outcomes of novel therapeutic procedures for Parkinson's disease (PD) was developed based on the Hoehn and Yahr (HY) stages of PD. Results provided support for model validity. Model application to a future dopamine cell replacement therapy indicated long-term cost offsets and gains in quality-adjusted life years (QALYs) in early onset PD (HY III-IV), as compared to standard drug therapy. The maximum price premium (i.e., profit or compensation for developmental costs) for the intervention to remain cost-effective was estimated to euro12000-64000 according to cost-per-QALY thresholds of euro38000-70000 and depending on whether all or only medical direct costs are considered. The study illustrates the value of early health economic modeling and the described model shows promise as a means to estimate outcomes and aid decision-making regarding novel interventions for PD.

  • 4.
    Sjödahl Hammarlund, Catharina
    et al.
    Lund University.
    Hagell, Peter
    Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap I. Kristianstad University, Research Environment PRO-CARE. Kristianstad University, Research Platform for Collaboration for Health.
    Nilsson, Maria H.
    Lund University.
    Motor and non-motor predictors of illness-related distress in Parkinson's disease2012In: Parkinsonism & Related Disorders, ISSN 1353-8020, E-ISSN 1873-5126, Vol. 18, no 3, p. 299-302Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To identify motor and non-motor symptoms independently associated with distress in Parkinson's disease (PD).

    METHOD: Clinical and patient-reported data from 118 people with PD (mean age and PD-duration, 64 and 8 years) were analyzed regarding associations with patient-reported distress using multiple regressions (controlling for age).

    RESULTS: Non-motor symptoms independently associated with distress were pain, fatigue, sleep, depression and anxiety (R(2), 0.81). The only significant motor aspect was mobility (R(2), 0.31). When considering both motor and non-motor symptoms, fatigue, pain, depression and sleep showed independent associations with distress (R(2), 0.76).

    CONCLUSION: Distress in PD is primarily associated with non-motor features.

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