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  • 1.
    Andersson, Camilla
    et al.
    Kristianstad University, School of Health and Society.
    Andersson, Kristina
    Kristianstad University, School of Health and Society.
    Existentiell smärta hos patienter med cancer i palliativt skede2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Pain in the end of life means not only the physical discomfort, but can also have psychological, social and existential dimensions. Existential pain plays a major role in palliative care. Dealing with the meaning of life, guilt and death can provide existential pain. The existential needs are as many studies indicate neglected. Health professionals often avoid these issues. The purpose of this study was to describe the existential pain in cancer patients in a palliative setting. Method: A literature review was conducted with qualitative articles. The results showed that existential pain was widespread. The informants experienced loneliness and guilt and the pain was often described in physical terms. The pain was also associated with loss of various functions. There were also thoughts about spirituality and fear of the unknown future. Discussion: It is important that the nurse is attentive to patient’s needs for closeness or lonely moments. Medical professionals can also help patients regain their autonomy by identifying the features that actually exist. Through conversation, the patient may receive strength to live the last days and to face the unknown future. The conclusion is that in order to identify and alleviate existential pain it requires a good knowledge in communication and pain management.

  • 2.
    Bolejko, Anetta
    et al.
    Skåne University Hospital Malmö.
    Hagell, Peter
    Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap I. Kristianstad University, Research Environment PRO-CARE.
    Wann-Hansson, Christine
    Malmö University.
    Zackrisson, Sophia
    Skåne University Hospital Malmö.
    Prevalence, long-term development, and predictors of psychosocial consequences of false-positive mammography among women attending population-based screening2015In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 24, no 9, p. 1388-97Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Cancer screening aims to detect cancer at an asymptomatic stage, although side effects from screening also occur. We investigated the prevalence, longitudinal development, and predictors of psychosocial consequences of false-positive breast cancer screening.

    METHODS: Three hundred ninety-nine women with false-positive screening mammography responded to the Consequences of Screening-Breast Cancer (COS-BC) questionnaire immediately after a negative diagnosis (free from breast cancer) following recall examination(s) (baseline), and 6 and 12 months later. Age-matched controls (n = 499) with a negative mammogram responded to the COS-BC at the same occasions. Five COS-BC scales (Sense of dejection, Anxiety, Behavioral, Sleep, and Existential values) were used as outcome measures.

    RESULTS: Women with false-positive mammography had consistently higher prevalence of all five consequences compared with controls (P < 0.001). The prevalences decreased between baseline and 6 months (P < 0.001) but were stable between 6 and 12 months (P ≥ 0.136). Early recall profoundly predicted long-term consequences for all five outcomes (OR, 3.05-10.31), along with dissatisfaction with information at recall (OR, 2.28-2.56), being foreign-born (OR, 2.35-3.71), and lack of social support (OR, 1.13-1.25).

    CONCLUSION: This 1-year longitudinal study shows that women experience psychosocial consequences of false-positive screening mammography. Early recall should be performed cautiously, and provision of information as well as social support may reduce psychosocial consequences.

    IMPACT: Although delivery of population-based screening reduces breast cancer mortality, it also raises the issue of its impact on the psychosocial well-being of healthy women. Our findings identify predictors that can be targeted in future efforts to reduce the side effects of mammographic screening.

  • 3.
    Emilsson, Mimmi
    et al.
    Kristianstad University, School of Health and Society.
    Hansson, Johanna
    Kristianstad University, School of Health and Society.
    Mötet mellan patienter med cancer och sjuksköterskan: en litteraturstudie om patienters upplevelser2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: When a person suffers from cancer their entire world changes. A lack of knowledge creates a feeling of not being able to adequately grasp the situation, which is why it is important that the nurse provides decent caregiving with emphasis on entirety and communication. Purpose: The purpose of the literature study was to describe patients' experiences of the nurse's approach in relation to cancer treatment at hospital. Method: A literature review that is based on ten qualitative articles. Result: Through analysis, three main categories were found: The importance of wide knowledge by the nurse, The importance of a good nursing relationship and The importance of good caretaking that benefits the patient's well-being and their will to participate. Method of discussion: The reason, as to why there were not many articles found on the subject matter, is due to the fact that there is more research conducted from the nurse's perspective. The preunderstanding was confirmed and the authors get more insight in how important two-way communication is. Discussion of result: The patient wishes to feel involvement from the nurse and a good relationship between the two arises when good communication exists

  • 4.
    Fridberg, Marie
    et al.
    Lund University.
    Tassidis, Helena
    Lund University.
    Gjörloff Wingren, Anette
    Malmö University.
    PTPN7 (protein tyrosine phosphatase, nonreceptor type 7)2010In: Atlas of Genetics and Cytogenetics in Oncology and Haematology, ISSN 0187-6236, E-ISSN 1768-3262, Vol. 14, no 11, p. 1032-1033Article in journal (Other academic)
  • 5.
    Koinberg, Inga-Lill
    et al.
    Kristianstad University, School of Health and Society.
    Engholm, G. B.
    Department of Oncology, University Hospital, Örebro.
    Genell, A.
    Oncological center west health care region, University hospital, Gothenburg.
    Holmberg, L.
    Department of surgical sciences, Uppsala University.
    A health economic evaluation of follow up after breast cancer surgery: result from of an rct study2008In: European Journal of Cancer Supplements, ISSN 1359-6349, Vol. 6, no 7, p. 167-Article in journal (Other academic)
    Abstract [en]

    Introduction: We studied the costs of following 264 breast cancer patients, stage I and II, randomised to two different follow-up programmes in a prospective trial, involving, on the one hand, routine follow-up visits to the physician with follow-up visits twice a year or more over five years (PG = physician group), and on the other, specialist nurse intervention with check-ups on demand (NG = nurse group). The trial period was 5 years. The women in the two intervention groups did not differ in anxiety and depression, their satisfaction with care, their experienced accessibility to the medical centre or their medical outcome as measured by recurrence or death.

    Patients and Methods: The analyses were done from different lists representing costs at three hospitals in Sweden according to the principles of a cost minimization study. Result: The cost per person year of follow-up differed between the groups, with €630 per person year in PG compared to €495 per person year in NG. Thus, specialist nurse intervention with check-ups on demand was 20% less expensive than routine follow-up visits to the physician. The main difference in cost between the groups was explained by the numbers of visits to the physician in the respective study arms. There were 21% more primary contacts in PG than NG.

    Discussion: The difference in cost per year and patient by study arm is modest, but transforms to nearly €9,000 per patient and 5-year period, offering a substantial opportunity for reallocating resources since breast cancer is the most prevalent tumour worldwide.

  • 6.
    Tassidis, Helena
    et al.
    Lund University.
    Brokken, Leon J. S.
    Lund University.
    Jirström, Karin
    Lund University.
    Ehrnström, Roy
    Lund University.
    Pontén, Fredrik
    Uppsala University.
    Ulmert, David
    Lund University.
    Bjartell, Anders
    Lund University.
    Härkönen, Pirkko
    Lund University.
    Gjörloff Wingren, Anette
    Lund University.
    Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer2010In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 126, no 10, p. 2296-2307Article in journal (Refereed)
    Abstract [en]

    The protein tyrosine kinase (PTK) receptors and cytosolic signaling proteins as well as the protein tyrosine phosphatases (PTPs) have important roles in regulation of growth of the benign and malignant prostate gland. Here, we studied expression of the protein tyrosine phosphatase SHP-1 in prostate cancer cell lines and in human prostatic tissues. SHP-1 is expressed at a high level in LNCaP prostate cancer cells compared with PC3 cells. Silencing of SHP-1 expression with siRNA in LNCaP cells led to an increased rate of proliferation, whereas overexpression of SHP-1 by means of transient and stable transfection in PC3 cells led to a decrease in proliferation. Corresponding changes were observed in cyclin D1 expression. We further demonstrate that LNCaP and PC3 cells respond differently to IL-6 stimulation. SHP-1 overexpression in PC3 cells reversed IL-6 stimulation of proliferation, whereas in SHP-1-silenced LNCaP cells, IL-6 inhibition of proliferation was not affected. In addition, IL-6 treatment led to higher levels of phosphorylated STAT3 in SHP-1-silenced LNCaP cells than in control cells. Next, SHP-1 expression in human prostate cancer was analyzed by immunohistochemical staining of tissue microarrays comprising tumor specimens from 100 prostate cancer patients. We found an inverse correlation between the tumor level of SHP-1 expression and time to biochemical recurrence and clinical progression among prostate cancer patients. In conclusion, our results suggest that a decreased level of SHP-1 expression in prostate cancer cells is associated with a high proliferation rate and an increased risk of recurrence or clinical progression after radical prostatectomy for localized prostate cancer.

  • 7.
    Tassidis, Helena
    et al.
    Lund University.
    Brokken, Leon
    Ulmert, David
    Ehrnström, Roy
    Jirström, Karin
    Bjartell, Anders
    Härkönen, Pirkko
    Gjörloff Wingren, Anette
    Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer2009In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 69, no 9 Supplement, p. LB-257-Article in journal (Other academic)
    Abstract [en]

    The protein tyrosine kinase (PTK) receptors and cytosolic signalling proteins as well as the protein tyrosine phosphatases (PTP) have important roles in regulation of growth and function of the benign and malignant prostate gland. Here we studied the expression levels and functions of the protein tyrosine phosphatase SHP-1 in prostate cancer cell lines and in benign and malignant human prostatic tissues. We found that SHP-1 is expressed at a high level in LNCaP prostate cancer cells compared to PC-3 cells. Silencing of SHP-1 expression with siRNA in LNCaP cells led to an increased rate of proliferation as measured by thymidine incorporation, whereas in PC3 cells in which SHP1 was overexpressed by transient transfection proliferation rate was decreased. We also examined SHP-1 expression in prostate cancer by immunohistochemical staining of tissue microarrays comprising tumor specimens from 122 prostate cancer patients. We found an inverse correlation between SHP-1 staining intensity and the time to biochemical recurrence as measured by a rise in the serum level of prostate-specific antigen (PSA) in prostate cancer patients. In conclusion, our results suggest that a low level of SHP-1 expression in prostate cancer cells is associated with high proliferation rate and with an increased risk of biochemical recurrence after radical prostatectomy for localized prostate cancer.

  • 8.
    Tassidis, Helena
    et al.
    Lund University.
    Culig, Zoran
    Österrike.
    Gjörloff Wingren, Anette
    Lund University.
    Härkönen, Pirkko
    Lund University.
    Role of the protein tyrosine phosphatase SHP-1 in Interleukin-6 regulation of prostate cancer cells2010In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 70, no 14, p. 1491-1500Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the modulation of growth and progression of prostate cancer. Decreased expression of the tyrosine phosphatase SHP-1, involved in regulation of cytokine and tyrosine kinase receptor signaling, has been shown to be associated with less favorable outcome among prostate cancer patients.

    METHODS: Parental LNCaP cells and an LNCaP-IL6+ subline, derived from parental LNCaP cells by continuous culture of the cells in the presence of recombinant IL-6 were used in the study. Expression of STAT3, pSTAT3, ERK, pERK, AKT, pAKT, PTEN, and SHP-1 was analyzed by immunohistochemistry, Western blots, cDNA microarray, quantitative PCRs, and reverse transcriptase PCRs. Proliferation and apoptosis of transfected cells were analyzed by caspase3/7 assay and flow cytometry.

    RESULTS: Phosphorylation of ERK and STAT3 was increased in the LNCaP-IL6+ subline compared with LNCaP cells, whereas pAKT was decreased. Overexpression and inhibition experiments with SHP-1 siRNA showed that SHP-1 reduced proliferation and increased apoptosis in both cell lines. Microarray analysis revealed 80 up-regulated and 87 down-regulated SHP-1-related genes in the LNCaP-IL6+ cell line compared with LNCaP cells.

    CONCLUSIONS: SHP-1 suppresses growth and increases apoptosis in both LNCaP and LNCaP-IL6+ cells, which suggests that SHP-1 could be a therapeutic target in prostate cancer, even when there is an IL-6-related growth advantage.

1 - 8 of 8
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