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Zinc transporter 8 autoantibodies in patients with type 1 diabetes from a multiethnic population and their first degree relatives
Brasilien.
Lund University.
Brasilien.
Brasilien.
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2014 (English)In: Arquivos brasileiros de endocrinologia e metabologia, ISSN 0004-2730, E-ISSN 1677-9487, Vol. 58, no 7, 737-743 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Zinc transporter 8 autoantibodies (ZnT8A) have been poorly studied in non-Caucasian individuals. We aimed to investigate the prevalence of ZnT8 autoantibodies in patients with T1D and their first degree relatives (FDR) from a multiethnic population, as well as its relation with the insulin (INS) or the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene polymorphisms.

SUBJECTS AND METHODS: ZnT8A were analyzed in sera from T1D patients (n = 72, mean age of 30.3 ± 11.4 years) of variable duration (15.7 ± 11.8 years) and their FDR (n = 78, mean age of 18.3 ± 9.1 years) by a triple mix Radioligand Binding Assay (RBA) for the ZnT8 autoantibody (ZnT8-RWQ) variants. SNP (single nucleotide polymorphism) for INS and PTPN22 were genotyped.

RESULTS: The prevalence of ZnT8A was higher in T1D patients than FDR, for ZnT8TripleA (24% vs. 4%,p = 0.001), ZnT8RA (24% vs. 4%, p < 0.001) and ZnT8QA (15% vs. 3%, p = 0.004). All FDR with ZnT8A (n = 3) had at least another positive antibody. Heterozygosis for PTPN22 was associated with a higher frequency of ZnT8TripleA (p = 0.039) and ZnT8RA (p = 0.038).

CONCLUSIONS: ZnT8A is observed in non-Caucasian patients with T1D, even years after the disease onset, as well as in their FDR. In those, there was an overlap between ZnT8A and other T1D antibodies. ZnT8A was associated with PTPN22 polymorphisms. Further longitudinal studies are necessary to elucidate the importance of these findings in the natural history of T1D patients with multiethnic background.

Place, publisher, year, edition, pages
2014. Vol. 58, no 7, 737-743 p.
Keyword [en]
Autoimmunity, diabetes, non-whites, ZnT8A, PTPN22
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:hkr:diva-15868DOI: 10.1590/0004-2730000003088ISI: 000344466000007PubMedID: 25372583OAI: oai:DiVA.org:hkr-15868DiVA: diva2:956959
Available from: 2016-08-31 Created: 2016-08-31 Last updated: 2017-01-12Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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  • modern-language-association-8th-edition
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More styles
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