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Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients
Lund University.
Lund University.ORCID iD: 0000-0002-9953-2829
Lund University.
Lund University.
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2015 (English)In: Pediatric Diabetes, ISSN 1399-543X, E-ISSN 1399-5448, Vol. 16, no 8, 621-628 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine neuropeptide Y (NPY-LA) and autoantibodies to proline neuropeptide Y (NPY-PA) on the diagnostic sensitivity of type 1 diabetes (T1D), (ii) the association of NPYA with major islet autoantibodies, and (iii) the association of NPYA with HLA-DQ genotypes in newly diagnosed T1D patients.

METHODS: Serum from the HLA-DQ typed T1D patients (n = 673; median age 10 yr) from Skåne, Sweden, were analyzed for autoantibodies against NPY-L and NPY-P in a radioligand binding assay, and against glutamic acid decarboxylase 65 (GAD65), insulin, insulinoma associated protein-2 (IA-2), and zinc transporter 8 (ZnT8) in addition to islet cell antibodies (ICA). A total of 1006 subjects (median age 9 yr) were used as controls.

RESULTS: A total of 9.2% (n = 62) of the T1D patients were positive for NPY-LA (p < 0.001) and 7.6% (n = 51) for NPY-PA (p < 0.001) compared to 1.1% (n = 11) in controls. The NPY-LA and NPY-PA appeared together (κ = 0.63; p < 0.001) and the median levels correlated (R² = 0.603; p < 0.001). T1D patients diagnosed after 10 yr of age were at an increased risk for NPYA at diagnosis [odds ratio (OR = 2.46; 95% CI 1.46-4.16; p = 0.001)] adjusted for age at diagnosis, gender, autoantibody positivity, and HLA.

CONCLUSIONS: NPY is a minor autoantigen in children with newly diagnosed T1D. Therefore, NPY autoantibodies may be investigated in T1D autoimmunity.

Place, publisher, year, edition, pages
2015. Vol. 16, no 8, 621-628 p.
Keyword [en]
HLA genotype; autoimmunity; minor autoantibodies; radioligand binding assay
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:hkr:diva-15869DOI: 10.1111/pedi.12222ISI: 000363929400009PubMedID: 25258030OAI: oai:DiVA.org:hkr-15869DiVA: diva2:956958
Available from: 2016-08-31 Created: 2016-08-31 Last updated: 2016-11-10Bibliographically approved

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