hkr.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Systemic inflammatory impact of periodontitis on acute coronary syndrome
Kristianstad University, School of Health and Society, Avdelningen för Oral hälsa och folkhälsovetenskap.
Kristianstad Central Hospital, Kristianstad.
England.
Kristianstad Central Hospital, Kristianstad.
Show others and affiliations
2016 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 43, no 9, 713-719 p.Article in journal (Refereed) Published
Abstract [en]

AIM: A causative relationship between acute coronary syndrome (ACS) and periodontitis has yet to be defined. The aim of this study was to assess differences in levels of serum cytokines between individuals with or without ACS or periodontal comorbidity.

MATERIAL AND METHODS: In a case-control study, individuals with ACS (78 individuals, 10.3% females) and matching healthy controls (78 individuals, 28.2% females) were included. Medical and dental examinations were performed to diagnose ACS and periodontitis. Serum levels of cytokines were assessed using Luminex technology.

RESULTS: A diagnosis of periodontitis in the ACS and control group was diagnosed in 52.6% and 12.8% of the individuals, respectively. The unadjusted odds-ratio that individuals with ACS also had periodontitis was 7.5 (95% CI: 3.4, 16.8, p<0.001). Independent of periodontal conditions, individuals with ACS had significantly higher serum levels of IL8 (mean: 44.3 and 40.0 pg/ml) and vascular endothelial growth factor (VEGF) (mean: 82.3 and 55.3 pg/ml) than control individuals. A diagnosis of periodontitis made no difference in serum cytokine expressions.

CONCLUSION: Elevated serum levels of VEGF were associated with ACS. Serum cytokine expression in individuals with ACS is unrelated to periodontal conditions. This article is protected by copyright. All rights reserved.

Place, publisher, year, edition, pages
2016. Vol. 43, no 9, 713-719 p.
Keyword [en]
VEGF; cardiovascular disease; cytokines; hs-CRP; human; oral disease; serum
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-15324DOI: 10.1111/jcpe.12540ISI: 000381034300001PubMedID: 26935585OAI: oai:DiVA.org:hkr-15324DiVA: diva2:910059
Available from: 2016-03-08 Created: 2016-03-08 Last updated: 2016-11-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Widén, CeciliaSättlin, SusannaRenvert, StefanPersson, G Rutger
By organisation
Avdelningen för Oral hälsa och folkhälsovetenskapResearch environment Oral Health - Public Health - Quality of Life (OHAL)
In the same journal
Journal of Clinical Periodontology
Dentistry

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 174 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf