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Weight stability in Parkinson's disease
Kristianstad University, School of Health and Society. Kristianstad University, Research Environment PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Kristianstad University, Research Platform for Collaboration for Health.ORCID iD: 0000-0001-6618-2116
Lund University.
Kristianstad University, Research Environment PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap I. Kristianstad University, Research Platform for Collaboration for Health.ORCID iD: 0000-0003-2174-372X
Kristianstad University, Research Environment PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Kristianstad University, School of Health and Society, Avdelningen för Sjuksköterskeutbildningarna. Kristianstad University, Research Platform for Collaboration for Health.ORCID iD: 0000-0003-4820-6203
2016 (English)In: Nutritional neuroscience, ISSN 1028-415X, E-ISSN 1476-8305, Vol. 19, no 1, 11-20 p.Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

Objectives: Parkinson's disease (PD) has traditionally been associated with weight loss. However, recent studies have not found any evidence of underweight in PD. Nevertheless, few studies have addressed nutritional status changes over time in relation to other clinical PD features. Here, we explore changes in nutritional status and motor and non-motor PD features (including dopaminergic drug therapy) in PD patients after 1 year. Methods: Motor and non-motor PD features, dopaminergic drug therapy, under-nutrition and malnutrition risk, and anthropometric measures (BMI, handgrip strength, triceps skin-fold, mid-arm circumference, and mid-upper arm muscle circumference) were assessed at baseline and 1 year later among 65 people with PD. Results: Disability, PD motor symptoms, dysautonomia, and dopaminergic drug therapy increased. Underweight was uncommon both at baseline (n= 3) and follow-up (n = 2); malnutrition risk was common but stable (88 and 92%), whereas triceps skin-fold increased (P = 0.030); mid-upper arm muscle circumference decreased (P = 0.002); and the proportion of people with low handgrip strength (P = 0.012) increased. Correlations between nutritional variables and motor and non-motor PD features were absent to modest. Multiple linear regression analysis showed that baseline pupillomotor functioning was associated with decreased weight and BMI, and sleep with increased weight and BMI. In addition, increases in anxiety were associated with decreased weight, BMI, and triceps skin-fold. Discussion: During the PD course, there seems to be redistribution in body composition from muscle to fat. Studies are needed to identify possible explanations for the findings. This implies that malnutrition should be regularly screened to identify those at risk of developing reduced muscle mass and increased morbidity.

Place, publisher, year, edition, pages
2016. Vol. 19, no 1, 11-20 p.
Keyword [en]
Parkinson's disease, weight, body composition, nutrition, protein intake
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hkr:diva-15258DOI: 10.1179/1476830515Y.0000000044ISI: 000368260800002PubMedID: 26339843OAI: oai:DiVA.org:hkr-15258DiVA: diva2:900947
Available from: 2016-02-05 Created: 2016-02-05 Last updated: 2017-01-11Bibliographically approved
In thesis
1. Nutritionsstatus och viktförändring vid Parkinsons sjukdom
Open this publication in new window or tab >>Nutritionsstatus och viktförändring vid Parkinsons sjukdom
2015 (Swedish)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Malmö: Institutionen för kliniska vetenskaper, Malmö, Lund universitet, 2015. 77 p.
Keyword
Parkinson, nutrition, viktförändring
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:hkr:diva-16230 (URN)
Presentation
2015-11-24, Malmö, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2016-11-16 Created: 2016-11-14 Last updated: 2016-11-17Bibliographically approved

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Lindskov, SusanneHagell, PeterWestergren, Albert
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School of Health and SocietyResearch Environment PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and EducationResearch Platform for Collaboration for HealthAvdelningen för Hälsovetenskap IAvdelningen för Sjuksköterskeutbildningarna
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