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Low expression of SHP-2 is associated with less favourable outcome of prostate cancer
Lund University.ORCID iD: 0000-0003-4190-5431
Lund University.
Lund University.
Skåne University Hospital, Malmö.
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2013 (English)In: Tumor Biology, ISSN 1010-4283, E-ISSN 1423-0380, Vol. 34, no 2, 637-642 p.Article in journal (Refereed) Published
Abstract [en]

Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is an important regulator of cell signaling because of its ability to dephosphorylate receptors of growth factors as well as the cytokines and tyrosine-phosphorylated proteins associated with these receptors. In the current study, we used four different prostate cancer cell lines: PC3, DU145, LNCaP and LNCaP-IL6+. Tumor specimens from 122 patients with prostate cancer were analyzed using a tissue microarray. Our data demonstrate that all four prostate cancer cell lines express the SHP-2 protein. Additionally, low staining intensity and SHP-2 expression in the cytoplasm of cancer cells in prostate tumor specimens was inversely correlated with prostate volume (p = 0.041 and p = 0.042, respectively) whereas nuclear staining was positively correlated with extracapsular extension (p = 0.039). In our post-prostatectomy specimens, we found that patients with low SHP-2 expression had less favorable outcomes with respect to biochemical recurrence and clinical progression (p = 0.005 and p = 0.018, respectively). The loss of cytoplasmic SHP-2 expression is associated with increased growth and prostatic cancer progression.

Place, publisher, year, edition, pages
2013. Vol. 34, no 2, 637-642 p.
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:hkr:diva-14765DOI: 10.1007/s13277-012-0590-1ISI: 000316364500004PubMedID: 23192641OAI: oai:DiVA.org:hkr-14765DiVA: diva2:856535
Available from: 2015-09-24 Created: 2015-09-24 Last updated: 2016-08-11Bibliographically approved

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Tassidis, Helena

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CiteExportLink to record
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  • apa
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