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Determination of thirteen antibiotics in drug products: a new LC-MS/MS tool for screening drug product quality
Faculty of Health and Medical Sciences, University of Copenhagen.
Faculty of Health and Medical Sciences, University of Copenhagen.
Faculty of Health and Medical Sciences, University of Copenhagen.
Faculty of Health and Medical Sciences, University of Copenhagen.
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2014 (English)In: Analytical Methods, ISSN 1759-9660, E-ISSN 1759-9679, Vol. 6, 5847-5855 p.Article in journal (Refereed) Published
Abstract [en]

Poor quality antibiotic medicines in circulation in Sub-Saharan Africa continue to be a burden. Pharmaceutical trade in substandard and counterfeit medicines is on the rise. The chemical quality of antibiotics dispensed in health facilities and recognised drug outlets in Ghana, when compromised, could be a major drawback to efforts made in fighting antibiotic resistance globally. To improve on antibiotic drug quality monitoring, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology, which is capable of quantifying thirteen antibiotics in drug products, was developed and validated in present work. The methodology was applied to various drug products including tablets, capsules, suspensions, syrups, intravenous and injection solutions as well as ear and eye droplets used as essential medicines in a Sub-Saharan country, Ghana.

Place, publisher, year, edition, pages
2014. Vol. 6, 5847-5855 p.
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:hkr:diva-14451DOI: 10.1039/C4AY00748DOAI: oai:DiVA.org:hkr-14451DiVA: diva2:846185
Available from: 2015-08-14 Created: 2015-08-13 Last updated: 2015-08-14Bibliographically approved

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Björklund, Erland
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CiteExportLink to record
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