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Cytokine expression in peri-implant crevicular fluid in relation to bacterial presence
Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap III. Kristianstad University, Research environment Oral Health - Public Health - Quality of Life. Blekinge Institute of Technology, Karlskrona.ORCID iD: 0000-0003-0992-2362
Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap III.
Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap III. Kristianstad University, Research environment Oral Health - Public Health - Quality of Life. Department of Periodontics, University of Washington, Seattle.ORCID iD: 0000-0002-3620-5978
2015 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 42, no 7, 697-702 p.Article in journal (Refereed) Published
Abstract [en]

AIM: The aim was to assess clinical inflammatory parameters, cytokine levels, and bacterial counts in samples from implant crevicular fluid in cases with untreated peri-implantitis.

MATERIAL AND METHODS: Several bacterial species known to up-regulate pro-inflammatory cytokines have been associated with peri-implantitis. The Luminex magnet bead technology was used to study cytokines in crevicular fluid. The checkerboard DNA-DNA hybridization method was used to study bacterial counts in samples from 41 implants (41 individuals).

RESULTS: Profuse bleeding and suppuration was found in 25/41 (61.0%) and 17/41 (41.5%) of the implants. The reliability of duplicate cytokine processing was high. In the presence of profuse bleeding, higher pg/ml levels of IL-1β (p = 0.016), IL-8 (p = 0.003), TNF-α (p = 0.024), and VEGF (p = 0.004) were found. Higher concentrations of IL-1β were found in the presence of suppuration, and if Escherichia coli (p = 0.001) or Staphylococcus epidermidis (p = 0.05) could be detected.

CONCLUSION: Profuse bleeding and/or suppuration in untreated peri-implantitis can be associated with higher concentrations of IL-1β, IL-8, TNF-α and VEGF in peri-implant crevicular fluid. A higher concentration of IL-1β in peri-implant crevicular fluid was found in samples that were positive for E. coli or S. epidermidis.

Place, publisher, year, edition, pages
2015. Vol. 42, no 7, 697-702 p.
Keyword [en]
bacteria, cytokines, inflammation, peri-implantitis
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-14148DOI: 10.1111/jcpe.12422ISI: 000358198500011PubMedID: 26085219OAI: oai:DiVA.org:hkr-14148DiVA: diva2:824770
Available from: 2015-06-22 Created: 2015-06-22 Last updated: 2015-09-03Bibliographically approved

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Renvert, StefanWidén, CeciliaPersson, G. Rutger
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Avdelningen för Hälsovetenskap IIIResearch environment Oral Health - Public Health - Quality of Life
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CiteExportLink to record
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