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The 39-Item Parkinson's Disease Questionnaire (PDQ-39): is it a unidimensional construct?
Department of Health Sciences, Lund University. (Forskningsmiljön PRO-CARE)ORCID iD: 0000-0003-2174-372X
Department of Health Sciences, Lund University.
2009 (English)In: Therapeutic advances in neurological disorders, ISSN 1756-2856, Vol. 2, no 4, 205-214 p.Article in journal (Refereed) Published
Abstract [en]

The 39-item Parkinson's Disease Questionnaire, and particularly its summary index (PDQ-39SI) is a widely used patient-reported clinical trial endpoint. A basic assumption when summing items into a total score is that they represent a common variable. We therefore assessed the unidimensionality of the PDQ-39SI using Rasch and confirmatory factor analysis. Both analyses showed model misfit. Adjustment for differential item functioning and disordered response category thresholds did not improve model fit, and residual analyses showed deviation from unidimensionality. These data indicate multidimensionality and challenge the interpretation and validity of PDQ-39SI scores. Clinicians and investigators should use and interpret the PDQ-39SI with caution.

Place, publisher, year, edition, pages
2009. Vol. 2, no 4, 205-214 p.
National Category
Neurology
Identifiers
URN: urn:nbn:se:hkr:diva-12777DOI: 10.1177/1756285609103726PubMedID: 21179529OAI: oai:DiVA.org:hkr-12777DiVA: diva2:741788
Available from: 2014-08-29 Created: 2014-08-29 Last updated: 2014-09-15Bibliographically approved

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