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Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years
Danmark.
Lunds universitet.ORCID iD: 0000-0002-9953-2829
USA.
Danmark.
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2012 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 96, no 2, 204-210 p.Article in journal (Refereed) Published
Abstract [en]

Aims: To test if islet autoantibodies at diagnosis of type 1 diabetes (T1DM) and after 3-6 years with T1D predict residual beta-cell function (RBF) after 3-6 years with T1D.

Methods: T1D children (n = 260, median age at diagnosis 9.4, range 0.9-14.7 years) were tested for GAD65, IA-2, ZnT8R, ZnT8W and ZnT8Q autoantibodies (A) at diagnosis, and 3-6 years after diagnosis when also fasting and stimulated RBF were determined.

Results: For every 1-year increase in age at diagnosis of TID, the odds of detectable C-peptide increased 1.21 (1.09, 1.34) times for fasting C-peptide and 1.28 (1.15, 1.42) times for stimulated C-peptide. Based on a linear model for subjects with no change in IA-2A levels, the odds of detectable C-peptide were 35% higher than for subjects whose IA-2A levels decreased by half (OR = 1.35 (1.09, 1.67), p = 0.006); similarly for ZnT8WA (OR = 1.39 (1.09, 1.77), p = 0.008) and ZnT8QA (OR = 1.55 (1.06, 2.26) p = 0.024). Such relationship was not detected for GADA or ZnT8RA. All OR adjusted for confounders.

Conclusions: Age at diagnosis with T1D was the major predictor of detectable C-peptide 3-6 years post-diagnosis. Decreases in IA-2A, and possibly ZnT8A, levels between diagnosis and post-diagnosis were associated with a reduction in RBF post-diagnosis.

Place, publisher, year, edition, pages
2012. Vol. 96, no 2, 204-210 p.
Keyword [en]
GAD65 autoantibodies; ZnT8 autoantibodies; Residual beta cell function; Age at diagnosis
National Category
Immunology in the medical area Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:hkr:diva-12664DOI: 10.1016/j.diabres.2011.12.013ISI: 000303668000026PubMedID: 22251574OAI: oai:DiVA.org:hkr-12664DiVA: diva2:739686
Available from: 2014-08-21 Created: 2014-08-21 Last updated: 2017-01-17Bibliographically approved

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CiteExportLink to record
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  • apa
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