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Impaired cytotoxicity in Papillon-Lefèvre syndrome
Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap.ORCID iD: 0000-0003-0992-2362
2005 (English)In: Journal of Dental Research, ISSN 0022-0345, E-ISSN 1544-0591, Vol. 84, no 5, 414-417 p.Article in journal (Refereed) Published
Abstract [en]

Papillon-Lefèvre syndrome (PLS), palmoplantar hyperkeratosis with periodontitis, has been genetically characterized. However, suspected associated immune dysfunctions remain elusive. The purpose of this study was to evaluate peripheral blood lymphocyte levels and natural killer (NK) cell cytotoxicity in PLS. Twenty patients and 20 healthy controls were examined. Peripheral blood lymphocytes were analyzed by flow cytometry for surface markers. NK cell cytotoxicity against K562 cells was determined by means of a 51Cr release assay. White blood cell differential and proportions of B-, T-, T-helper, T-suppressor, and NK cells revealed only sporadic borderline variations from control values. In contrast, NK cell cytotoxicity was consistently and severely depressed (32-53% of control values) in all patients. To the best of our knowledge, this newly described impairment of NK cell cytotoxic function is the first consistent immune dysfunction reported in PLS. This suggests that the impaired NK cell cytotoxicity might contribute to the pathogenesis of PLS-associated periodontitis.

Place, publisher, year, edition, pages
2005. Vol. 84, no 5, 414-417 p.
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-12434PubMedID: 15840775OAI: oai:DiVA.org:hkr-12434DiVA: diva2:734777
Available from: 2014-07-21 Created: 2014-07-21 Last updated: 2014-07-21Bibliographically approved

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