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Prefrontal hyperactivation during a working memory task in early-onset schizophrenia spectrum disorders: an fMRI study.
Oslo University Hospital & University of Oslo, Norway & Charité Universitätsmedizin, Berlin, Germany.ORCID iD: 0000-0001-6841-1808
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2011 (English)In: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 194, no 3, 257-262 p.Article in journal (Refereed) Published
Abstract [en]

Working memory (WM) dysfunction is increasingly recognized as a core feature of schizophrenia, but few studies have investigated prefrontal activation during WM tasks in early-onset schizophrenia spectrum disorder (EOS). Our aim was to explore prefrontal activation during a WM-task in EOS patients compared to healthy controls using functional magnetic resonance imaging (fMRI). Fifteen patients with EOS and 15 matched healthy controls performed a 0-back and a 2-back task while fMRI data were acquired. Results indicated that even though performance between patients and controls was comparable on both tasks, there was a hyperactivation in patients' ventrolateral prefrontal cortex (VLPFC) during the 2-back task compared to healthy controls. This pattern of activation suggests that, in patients with EOS, the VLPFC compensated in order to match performance of the controls. The activations in the EOS group may reflect the use of a compensatory, cognitive strategy while solving WM-tasks.

Place, publisher, year, edition, pages
2011. Vol. 194, no 3, 257-262 p.
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Neurosciences
Identifiers
URN: urn:nbn:se:hkr:diva-12346DOI: 10.1016/j.pscychresns.2011.05.011ISI: 000298522600008PubMedID: 22079661OAI: oai:DiVA.org:hkr-12346DiVA: diva2:732644
Available from: 2014-07-04 Created: 2014-07-04 Last updated: 2017-12-05Bibliographically approved

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Jensen, Jimmy

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