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Aberrant Effective Connectivity in Schizophrenia Patients during Appetitive Conditioning
Centre for Addiction and Mental Health, Toronto, ON, Canada & Charité Universitätsmedizin, Berlin, Germany.ORCID iD: 0000-0001-6841-1808
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2011 (English)In: Frontiers in human neuroscience, ISSN 1662-5161, Vol. 4, 239- p.Article in journal (Refereed) Published
Abstract [en]

It has recently been suggested that schizophrenia involves dysfunction in brain connectivity at a neural level, and a dysfunction in reward processing at a behavioral level. The purpose of the present study was to link these two levels of analyses by examining effective connectivity patterns between brain regions mediating reward learning in patients with schizophrenia and healthy, age-matched controls. To this aim, we used functional magnetic resonance imaging and galvanic skin recordings (GSR) while patients and controls performed an appetitive conditioning experiment with visual cues as the conditioned (CS) stimuli, and monetary reward as the appetitive unconditioned stimulus (US). Based on explicit stimulus contingency ratings, conditioning occurred in both groups; however, based on implicit, physiological GSR measures, patients failed to show differences between CS+ and CS- conditions. Healthy controls exhibited increased blood-oxygen-level dependent (BOLD) activity across striatal, hippocampal, and prefrontal regions and increased effective connectivity from the ventral striatum to the orbitofrontal cortex (OFC BA 11) in the CS+ compared to the CS- condition. Compared to controls, patients showed increased BOLD activity across a similar network of brain regions, and increased effective connectivity from the striatum to hippocampus and prefrontal regions in the CS- compared to the CS+ condition. The findings of increased BOLD activity and effective connectivity in response to the CS- in patients with schizophrenia offer insight into the aberrant assignment of motivational salience to non-reinforced stimuli during conditioning that is thought to accompany schizophrenia.

Place, publisher, year, edition, pages
2011. Vol. 4, 239- p.
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:hkr:diva-12333DOI: 10.3389/fnhum.2010.00239PubMedID: 21267430OAI: oai:DiVA.org:hkr-12333DiVA: diva2:732328
Available from: 2014-07-03 Created: 2014-07-03 Last updated: 2014-07-22Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf