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Correlates of periodontal decline and biologic markers in older adults.
University of Bern, Bern, Switzerland & University of Washington, Seattle, WA, USA.ORCID iD: 0000-0002-3620-5978
2008 (English)In: Journal of Periodontology, ISSN 0022-3492, Vol. 79, no 10, 1920-1926 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: There is limited information on infectious and host responses distinguishing older people with or without active periodontitis. This study measured bacterial and serum cytokine and high-sensitivity C-reactive protein (hsCRP) levels in older persons.

METHODS: Elders (mean age: 67 years), whose periodontal status had declined most or least (20% worst or 20% best) over 5 years, were enrolled. Two years later, they were classified as periodontally declining (active periodontitis [AP]), if they had at least five teeth with probing depth (PD) > or =5 mm, or stable (stable periodontally [SP]), if they did not. Groups were compared with respect to demographics, PD, clinical loss of attachment, subgingival bacteria, serum hsCRP, interleukin (IL)-1beta and -6, and chronic diseases.

RESULTS: Ten AP and 24 SP subjects were identified; 13% of women and 44% of men from the original sample were in the AP group (P <0.05). Most Asians were SP; most whites and all African Americans were classified as having AP (P <0.01). More AP elders had osteoporosis (P <0.01), but the AP and SP groups did not differ with respect to IL-1beta and -6 or hsCRP. Bacterial counts were higher in the AP group for Parvimonas micra (previously Peptostreptococcus micros or Micromonas micros) (7.7 x 10(5) cells versus 3.8 x 10(5) cells; P <0.05), Prevotella intermedia (25.7 x 10(5) cells versus 9.8 x 10(5) cells; P <0.01), Tannerella forsythia (previously T. forsythensis) (16.2 x 10(5) cells versus 8.0 x 10(5) cells; P <0.05), and Streptococcus mutans (6.2 x 10(5) cells versus 2.0 x 10(5) cells; P <0.01). Three risk factors were most predictive of periodontal decline: PD, osteoporosis, and being white or African American.

CONCLUSION: Periodontal decline was associated with osteoporosis, ethnicity, PD, gender, serum hsCRP, and levels of four bacterial species.

Place, publisher, year, edition, pages
2008. Vol. 79, no 10, 1920-1926 p.
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-12276DOI: 10.1902/jop.2008.080005ISI: 000260142100013PubMedID: 18834247OAI: oai:DiVA.org:hkr-12276DiVA: diva2:729927
Available from: 2014-06-26 Created: 2014-06-26 Last updated: 2014-09-18Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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