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Microbiological composition associated with interleukin-1 gene polymorphism in subjects undergoing supportive periodontal therapy.
University of Bern, Bern, Switzerland & University of Washington, Seattle, WA, USA.ORCID iD: 0000-0002-3620-5978
2006 (English)In: Journal of Periodontology, ISSN 0022-3492, Vol. 77, no 8, 1397-1402 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Interleukin-1 gene polymorphism (IL-1 gene) has been associated with periodontitis. The present study examined the subgingival microbiota by IL-1 gene status in subjects undergoing supportive periodontal therapy (SPT).

METHODS: A total of 151 subjects with known IL-1 gene status (IL-1A +4845/IL-1B -3954) (IL-1 gene) were included in this study. Clinical data and subgingival plaque samples (40 taxa) were collected. These taxa were determined by the checkerboard DNA-DNA hybridization method.

RESULTS: Gender, smoking habits (n-par tests), age, and clinical periodontal conditions did not differ by IL-1 gene status. IL-1 gene-negative subjects had a higher total bacterial load (mean difference, 480.4 x 10(5); 95% confidence interval [CI], 77 to 884 x 10(5); P <0.02). The levels of Actinobacillus actinomycetemcomitans (mean difference, 30.7 x 10(5); 95% CI, 2.2 to 59.5 x 10(5); P <0.05), Eubacterium nodatum (mean difference, 4.2 x 10(5); 95% CI, 0.6 to 7.8 x 10(5); P <0.02), Porphyromonas gingivalis (mean difference, 17.9 x 10(5); 95% CI, 1.2 to 34.5 x 10(5); P <0.05), and Streptococcus anginosus (mean difference, 4.0 x 10(5); 95% CI, 0.2 to 7.2 x 10(5); P <0.05) were higher in IL-1 gene-negative subjects, an observation specifically found at sites with probing depths <5.0 mm.

CONCLUSIONS: Bleeding on probing did not differ by IL gene status, reflecting clinical SPT efficacy. IL-1 gene-negative subjects had higher levels of periodontal pathogens. This may suggest that among subjects undergoing SPT, a lower bacterial load is required in IL-1 gene-positive subjects to develop the same level of periodontitis as in IL-1 gene-negative subjects.

Place, publisher, year, edition, pages
2006. Vol. 77, no 8, 1397-1402 p.
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-12269DOI: 10.1902/jop.2006.050212ISI: 000241879300014PubMedID: 16881809OAI: oai:DiVA.org:hkr-12269DiVA: diva2:729894
Available from: 2014-06-26 Created: 2014-06-26 Last updated: 2014-09-18Bibliographically approved

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