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High-sensitivity serum C-reactive protein levels in subjects with or without myocardial infarction or periodontitis.
Departments of Periodontics and Oral Medicine, University of Washington, Seattle, WA, USA & Department of Periodontology and Fixed Prosthodontics, School of Dental Medicine, University of Bern, Bern, Switzerland.ORCID iD: 0000-0002-3620-5978
Department of Medicine, Kristianstad Central Hospital, Kristianstad, Sweden.
Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap. Department of Medicine, Kristianstad Central Hospital, Kristianstad, Sweden.
Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap.ORCID iD: 0000-0003-0992-2362
2005 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 32, no 3, 219-224 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Serum high-sensitivity C-reactive protein (hsC-rp) is a non-specific marker of inflammation. Elevated hsC-rp levels are found in subjects with cardiovascular diseases (CVDs). Periodontitis may influence hsC-rp levels.

OBJECTIVES: To assess periodontal status and hsC-rp serum levels in consecutive subjects hospitalized and diagnosed with acute myocardial infarction (AMI) (n=85) and in a group of carefully matched subjects (gender, age social, ethnic, and smoking habits) without clinical evidence of CVD (n=63).

METHODS: hsC-rp levels, other routine serum values, and clinical periodontal conditions were studied.

RESULTS: Subjects with AMI had higher hsC-rp levels than control subjects (p<0.001, Mann-Whitney U-test). The odds that subjects in the control group with periodontitis (30% or more sites with>4.0 mm loss of alveolar bone) had serum hsC-rp>1.8 mg/l was 1.5 (95% CI: 1.1-7.3, p<0.05). Stepwise linear regression analysis failed to include periodontal parameters in an explanatory model to hsC-rp values. Only the serum leucocyte (white blood cell (WBC)) counts were explanatory to hsC-rp values (beta standard coefficient=0.45, t=3.2, p<0.001). Serum WBC counts were significantly higher in control subjects with periodontitis (p<0.03) but not in subjects in the AMI group (p<0.57).

CONCLUSIONS: (1) As expected, elevated serum hsC-rp concentration and serum WBC counts are associated with acute coronary heart disease. (2) Elevated serum hsC-rp values are associated with radiographically defined periodontitis in subjects with no evidence of CVD. (3) Periodontal parameters are not explanatory to elevated serum hsC-rp values if serum WBC and low-density lipoprotein counts are included in the regression model.

Place, publisher, year, edition, pages
2005. Vol. 32, no 3, 219-224 p.
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-12253DOI: 10.1111/j.1600-051X.2005.00648.xISI: 000227534000001PubMedID: 15766362OAI: oai:DiVA.org:hkr-12253DiVA: diva2:729813
Available from: 2014-06-26 Created: 2014-06-26 Last updated: 2014-09-18Bibliographically approved

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Persson, G. RutgerOhlsson, OlaRenvert, Stefan
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