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Periodontitis vaccine decreases local prostaglandin E2 levels in a primate model.
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2004 (English)In: Infection and Immunity, ISSN 0019-9567, E-ISSN 1098-5522, Vol. 72, no 2, 1166-1168 p.Article in journal (Refereed) Published
Abstract [en]

Interleukin-1beta, tumor necrosis factor alpha, prostaglandin E2 (PGE2), and Porphyromonas gingivalis-specific immunoglobulin G levels in gingival crevicular fluid were measured in primates immunized with a P. gingivalis vaccine followed by ligature-induced periodontitis. Only PGE2 levels were dramatically suppressed (P < 0.0001) in immunized animals versus controls. A significant correlation (P < 0.027) was also found between PGE2 levels and decreased bone loss scores. This study presents the first evidence of a potential mechanism involved in periodontitis vaccine-induced suppression of bone loss in a nonhuman primate model and offers insight into the role of PGE2 in periodontal destruction.

Place, publisher, year, edition, pages
2004. Vol. 72, no 2, 1166-1168 p.
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-12251DOI: 10.1128/IAI.72.2.1166-1168.2004ISI: 000188766400068PubMedID: 14742568OAI: oai:DiVA.org:hkr-12251DiVA: diva2:729804
Available from: 2014-06-26 Created: 2014-06-26 Last updated: 2014-09-18Bibliographically approved

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Persson, G. Rutger
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