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Subgingival microflora in inflammatory bowel disease patients with untreated periodontitis.
Univ Estado Rio De Janeiro, Fac Odontol, Dept Periodontol, BR-20551030 Rio De Janeiro, Brazil.
Univ Fed Rio de Janeiro, Fac Med, Dept Gastroenterol, Rio De Janeiro, Brazil.
Univ Estado Rio De Janeiro, Fac Med, Dept Gastroenterol, BR-20551030 Rio De Janeiro, Brazil.
Univ Estado Rio De Janeiro, Fac Odontol, Dept Periodontol, BR-20551030 Rio De Janeiro, Brazil.
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2013 (English)In: European Journal of Gastroenterology and Hepathology, ISSN 0954-691X, E-ISSN 1473-5687, Vol. 25, no 2, 239-245 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To analyze the subgingival microflora composition of inflammatory bowel disease (IBD) patients with untreated chronic periodontitis and compare them with systemically healthy controls also having untreated chronic periodontitis.

METHOD: Thirty IBD patients [15 with Crohn's disease (CD) and 15 with ulcerative colitis (UC)] and 15 control individuals participated in the study. All patients had been diagnosed with untreated chronic periodontitis. From every patient, subgingival plaque was collected from four gingivitis and four periodontitis sites with paper points. Samples from the same category (gingivitis or periodontitis) in each patient were pooled together and stored at -70 °C until analysis using a checkerboard DNA-DNA hybridization technique for 74 bacterial species.

RESULTS: Multiple-comparison analysis showed that the groups differed in bacterial counts for Bacteroides ureolyticus, Campylobacter gracilis, Parvimonas micra, Prevotella melaninogenica, Peptostreptococcus anaerobius, Staphylococcus aureus, Streptococcus anginosus, Streptococcus intermedius, Streptococcus mitis, Streptococcus mutans, and Treponema denticola (P<0.001). CD patients had significantly higher levels of these bacteria than UC patients either in gingivitis or in periodontitis sites (P<0.05). CD patients harbored higher levels of P. melaninogenica, S. aureus, S. anginosus, and S. mutans compared with controls both at gingivitis and at periodontitis sites (P<0.05). UC patients harbored higher levels of S. aureus (P=0.01) and P. anaerobius (P=0.05) than controls only in gingivitis sites.

CONCLUSION: Our study showed that even with similar clinical periodontal parameters, IBD patients harbor higher levels of bacteria that are related to opportunistic infections in inflamed subgingival sites that might be harmful for the crucial microbe-host interaction.

Place, publisher, year, edition, pages
2013. Vol. 25, no 2, 239-245 p.
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-12236DOI: 10.1097/MEG.0b013e32835a2b70ISI: 000312794400017PubMedID: 23060013OAI: oai:DiVA.org:hkr-12236DiVA: diva2:728722
Available from: 2014-06-24 Created: 2014-06-24 Last updated: 2014-09-18Bibliographically approved

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