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Pro-inflammatory biomarkers during experimental gingivitis in patients with type 1 diabetes mellitus: a proof-of-concept study.
University of Bern, Bern, Switzerland.
University of Michigan, Ann Arbor, MI, USA.
University of Michigan, Ann Arbor, MI, USA.
University of Michigan, Ann Arbor, MI, USA.
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2010 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 37, no 1, p. 9-16Article in journal (Refereed) Published
Abstract [en]

AIM: To compare gingival crevicular fluid (GCF) biomarker levels and microbial distribution in plaque biofilm (SP) samples for subjects with type 1 diabetes (T1DM) versus healthy subjects without diabetes during experimental gingivitis (EG).

MATERIALS AND METHODS: A total of nine T1DM patients and nine healthy controls of age and gender similar to the T1DM patients were monitored for 35 days during EG. Hygiene practices were stopped for 3 weeks, and GCF, SP, plaque index (PI) and gingival index were determined. IL-1beta, IL-8, MMP-8 and MMP-9 were quantified by enzyme-linked immunosorbent assay, and SP samples were assessed by DNA-DNA hybridization for a panel of 40 subgingival microbial species.

RESULTS: IL-1beta levels in T1DM patients were elevated compared with healthy individuals, and showed differences between groups at 7-21 days while healthy patients showed IL-1beta increases from baseline to 14-21 days (p<0.05). Differences were observed in MMP-9 levels between patients with and without T1DM at 7-14 days (p<0.05). Orange complex species and PI measurements displayed a superior correlation with biomarker levels when compared with other complexes or clinical measurements during EG.

CONCLUSIONS: The mean GCF biomarker levels for IL-1beta and MMP-8 were most significantly elevated in T1DM subjects compared with healthy individuals during EG, not resulting from differences in the mean PI or microbial composition.

Place, publisher, year, edition, pages
2010. Vol. 37, no 1, p. 9-16
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-12229DOI: 10.1111/j.1600-051X.2009.01500.xISI: 000272771700002PubMedID: 19958441OAI: oai:DiVA.org:hkr-12229DiVA, id: diva2:728538
Available from: 2014-06-24 Created: 2014-06-24 Last updated: 2017-12-05Bibliographically approved

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Persson, G. Rutger

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CiteExportLink to record
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