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Analytical sample preparation strategies for the determination of antimalarial drugs in human whole blood, plasma and urine
Danmark.
Danmark.
Danmark.
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2014 (English)In: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 962, 109-131 p.Article in journal (Refereed) Published
Abstract [en]

Antimalarial drugs commonly referred to as antimalarials, include a variety of compounds with different physicochemical properties. There is a lack of information on antimalarial distribution in the body over time after administration, e.g. the drug concentrations in whole blood, plasma, and urine, which must be improved in order to advance curing the parasitic disease malaria. A key problem also lies in that pharmacokinetic studies not always are performed in patient groups that may benefit most of the treatment such as children, pregnancy and lower-weight ethnic populations. Here we review the available sample preparation strategies combined with liquid chromatographic (LC) analysis to determine antimalarials in whole blood, plasma and urine published over the last decade. Sample preparation can be done by protein precipitation, solid-phase extraction, liquid-liquid extraction or dilution. After LC separation, the preferred detection tool is tandem mass spectrometry (MS/MS) but other detection methods have been used e.g. UV, fluorescence and electrochemical detection. Major trends for sample preparation of the different groups of antimalarials for each matrix and its detection have been summarized. Finally, the main problems that the researchers have dealt with are highlighted. This information will aid analytical chemists in the development of novel methods for determining existing antimalarials and upcoming new drugs

Place, publisher, year, edition, pages
2014. Vol. 962, 109-131 p.
Keyword [en]
sample preparation, antimalarials, blood, plasma, urine
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:hkr:diva-11908DOI: 10.1016/j.jchromb.2014.02.048ISI: 000338406800016PubMedID: 24911547OAI: oai:DiVA.org:hkr-11908DiVA: diva2:709455
Available from: 2014-04-01 Created: 2014-04-01 Last updated: 2017-04-20Bibliographically approved

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Björklund, Erland
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Avdelningen för NaturvetenskapPlattformen för molekylär analys
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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf