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Clinical and microbiological results following nonsurgical periodontal therapy with or without local administration of piperacillin/tazobactam
Department of Periodontology, University of Bern.
Department of Periodontology, University of Bern.
Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap. Kristianstad University, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet.ORCID iD: 0000-0002-3620-5978
2013 (English)In: Clinical Oral Investigations, ISSN 1432-6981, E-ISSN 1436-3771, Vol. 17, no 7, 1645-1660 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: We assessed if adjunct administration of piperacillin/tazobactam added clinical and microbiological treatment benefits.

MATERIALS AND METHODS: Thirty-six subjects (mean age 52.1 years (SD ± 10.3)) (NS by group) with chronic periodontitis were randomly enrolled receiving subgingival debridement and the local administration of piperacillin/tazobactam (test group) or debridement alone (control group). Bleeding on probing (BOP), probing pocket depth (PPD), and microbiological counts of 74 species were studied by checkerboard DNA-DNA hybridization up to month 6 after treatment.

RESULTS: Mean PPD changes between baseline and month 6 in the test and control groups were 1.5 and 1.8 mm, respectively (NS between groups). BOP in both groups decreased from about 80 to 40 %. At 4 and 12 weeks, lower counts of the following bacteria were found in the test group (site level): Fusobacterium species, Parvimonas micra, Pseudomonas aeruginosa, Staphylococcus aureus, Tannerella forsythia, Treponema denticola, and a composite load of nine pathogens (p < 0.001). At week 26, subjects receiving local antibiotics had a lower prevalence at tested sites for Fusobacterium nucleatum sp. polymorphum, Fusobacterium periodonticum, P. micra, and T. denticola.

CONCLUSIONS: At 26 weeks, treatment with or without piperacillin/tazobactam resulted in similar BOP and PPD improvements. At week 26 and at the subject level, the prevalence of 4/74 pathogens was found at lower counts in the group receiving local antibiotics.

CLINICAL RELEVANCE: Administration of piperacillin/tazobactam reduces the prevalence of Fusobacterium, P. micra, and T. denticola to a greater extent than debridement alone but with no short-term differences in PPD or BOP.

Place, publisher, year, edition, pages
2013. Vol. 17, no 7, 1645-1660 p.
Keyword [en]
Periodontitis, Debridement, Local antibiotics, Piperacillin/tazobactam, Microbiota, Checkerboard DNA-DNA
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-11118DOI: 10.1007/s00784-012-0856-4ISI: 000323274000003PubMedID: 23334268OAI: oai:DiVA.org:hkr-11118DiVA: diva2:648175
Available from: 2013-09-13 Created: 2013-09-13 Last updated: 2014-09-18Bibliographically approved

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Persson, G. Rutger
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Avdelningen för HälsovetenskapForskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet
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CiteExportLink to record
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