This project deals with E-health web application framework, cloud platform and responsive web design which aim to adjust the presentation on mobile devices. This work presents the whole development process of the self-care management web-app framework which provides instructive supports for future other E-health field application. The report consists of the following main parts: analysis, design and implementation, and evaluation. Literature review and internet search are main methods for making an investigation on existing systems and related works. A prototype is developed by using .Net, CSS3, Java script and HTML5 technologies. The system test and evaluation is made to show the system’s usability.