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Abiotic degradation of antibiotic ionophores
Toxicology Laboratory, Analytical Biosciences, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen.
Eurofins Denmark A/S, Environment, Vejen.
Kristianstad University, School of Education and Environment, Avdelningen för Naturvetenskap.
Toxicology Laboratory, Analytical Biosciences, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen.
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2013 (English)In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 182, 177-183 p.Article in journal (Refereed) Published
Abstract [en]

Hydrolytic and photolytic degradation were investigated for the ionophore antibiotics lasalocid, monensin, salinomycin, and narasin. The hydrolysis study was carried out by dissolving the ionophores in solutions of pH 4, 7, and 9, followed by incubation at three temperatures of 6, 22, and 28 °C for maximum 34 days. Using LC–MS/MS for chemical analysis, lasalocid was not found to hydrolyse in any of the tested environments. Monensin, salinomycin, and narasin were all stable in neutral or alkaline solution but hydrolysed in the solution with a pH of 4. Half-lives at 25 °C were calculated to be 13, 0.6, and 0.7 days for monensin, salinomycin, and narasin, respectively. Absorbance spectra from each compound indicated that only lasalocid is degraded by photolysis (half-life below 1 h) due to an absorbance maximum around 303 nm, and monensin, salinomycin, and narasin are resistant to direct photolysis because they absorb light of environmentally irrelevant wavelengths.

Place, publisher, year, edition, pages
2013. Vol. 182, 177-183 p.
Keyword [en]
Ionophore, Degradation, Hydrolysis, Photolysis, LC–MS/MS
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:hkr:diva-10820DOI: 10.1016/j.envpol.2013.06.040ISI: 000326661700021PubMedID: 23917220OAI: oai:DiVA.org:hkr-10820DiVA: diva2:639437
Available from: 2013-08-07 Created: 2013-08-07 Last updated: 2015-08-10Bibliographically approved

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CiteExportLink to record
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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
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  • de-DE
  • en-GB
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Output format
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