hkr.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Subgingival Aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease
Institute of Dentistry, University of Helsinki.
Institute of Dentistry, University of Helsinki.
Institute of Dentistry, University of Helsinki.
Kristianstad University, School of Health and Society, Avdelningen för Hälsovetenskap. Kristianstad University, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet.ORCID iD: 0000-0002-3620-5978
Show others and affiliations
2013 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 40, no 6, 583-590 p.Article in journal (Refereed) Published
Abstract [en]

Aim We investigated the association between angiographically verified coronary artery disease (CAD) and subgingival Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola. Materials and Methods The cross-sectional study population (n = 445) comprised 171 (38.4%) patients with Stable CAD, 158 (35.5%) with acute coronary syndrome (ACS) and 116 (26.1%) with no significant CAD (No CAD). All patients participated in clinical and radiological oral health examinations. Pooled subgingival bacterial samples were analysed by checkerboard DNA–DNA hybridization assays. Results In all study groups, the presence of P. gingivalis, T. forsythia and T. denticola indicated a significant (p ≤ 0.001) linear association with the extent of alveolar bone loss (ABL), but A. actinomycetemcomitans did not (p = 0.074). With a threshold level of bacterial cells 1 × 105 A. actinomycetemcomitans was significantly more prevalent in the Stable CAD group (42.1%) compared to the No CAD group (30.2%) (p = 0.040). In a multi-adjusted logistic regression analysis using this threshold, A. actinomycetemcomitans positivity associated with Stable CAD (OR 1.83, 95% CI 1.00–3.35, p = 0.049), but its level or levels of other bacteria did not. Conclusions The presence of subgingival A. actinomycetemcomitans associates with an almost twofold risk of Stable CAD independently of alveolar bone loss.

Place, publisher, year, edition, pages
2013. Vol. 40, no 6, 583-590 p.
Keyword [en]
Aggregatibacter actinomycetemcomitans, angiography, coronary artery disease, DNA–DNA hybridization, subgingival bacteria
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-10498DOI: 10.1111/jcpe.12098ISI: 000318514600003PubMedID: 23521427OAI: oai:DiVA.org:hkr-10498DiVA: diva2:620226
Available from: 2013-05-08 Created: 2013-05-08 Last updated: 2014-09-18Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Persson, G. Rutger
By organisation
Avdelningen för HälsovetenskapForskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet
In the same journal
Journal of Clinical Periodontology
Dentistry

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 147 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf