hkr.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effect of probiotic lozenges on inflammatory reactions and oral biofilm during experimental gingivitis
Maxillofacial unit, Halland Hospital, Halmstad.
Maxillofacial unit, Halland Hospital, Halmstad.
Department of Dental Medicine, Karolinska Institutet.
Department of Odontology, Oral microbiology, Sahlgenska Academy at Gothenburg University.
Show others and affiliations
2013 (English)In: Acta Odontologica Scandinavica, ISSN 0001-6357, Vol. 71, no 3-4, 828-833 p.Article in journal (Refereed) Published
Abstract [en]

Aim. Probiotic bacteria have been introduced for prevention and treatment of periodontal diseases. The aim was to assess if daily oral administration of probiotic bacteria could influence the inflammatory response and the composition of supragingival plaque in an experimental gingivitis model. Materials and methods. Eighteen healthy female adults volunteered after informed consent. A double-blind randomized placebo-controlled cross-over design was used. The buccal surface of first molars was used as experimental sites. A mouth-guard covering the first premolar to second molar was used when brushing, preventing accidental cleaning during 3 weeks of plaque accumulation. Lozenges containing L. reuteri (ATCC55730 and ATCC PTA5289) or placebo were taken twice a day. During the run-in and washout periods, professional tooth cleaning was performed 5 days/week. At baseline and follow-up, plaque index, gingival index and bleeding on probing were recorded. Samples of gingival crevicular fluid (GCF) were analysed for concentration of seven inflammatory mediators. Bacterial samples were processed with checkerboard DNA/DNA-hybridization. Results. All subjects presented a local plaque accumulation and developed manifest gingivitis at the test sites during the intervention periods. The volume of GCF increased in both groups but was statistically significant only in the placebo group (p < 0.05). The concentrations of IL1-β and IL-18 increased significantly (p < 0.05), while IL-8 and MIP1-β decreased (p < 0.05). No differences were displayed between test and placebo. Likewise, the microbial composition did not differ between the groups. Conclusion. Daily intake of probiotic lozenges did not seem to significantly affect the plaque accumulation, inflammatory reaction or the composition of the biofilm during experimental gingivitis.

Place, publisher, year, edition, pages
2013. Vol. 71, no 3-4, 828-833 p.
Keyword [en]
bacteriotherapy, cytokines, gingival crevicular fluid, lactobacilli, plaque
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-10497DOI: 10.3109/00016357.2012.734406ISI: 000322832200067PubMedID: 23294143OAI: oai:DiVA.org:hkr-10497DiVA: diva2:620217
Available from: 2013-05-08 Created: 2013-05-08 Last updated: 2014-05-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Renvert, Stefan
By organisation
Avdelningen för HälsovetenskapForskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet
In the same journal
Acta Odontologica Scandinavica
Dentistry

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 62 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf