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Poor reproducibility of allergic rhinitis SNP associations
Kristianstad University, School of Education and Environment, Avdelningen för Naturvetenskap. Kristianstad University, Forskningsmiljön Biomedicin.
Department of Biological Sciences, National University of Singapore.
Kristianstad University, School of Education and Environment, Avdelningen för Naturvetenskap. Kristianstad University, Forskningsmiljön Biomedicin.ORCID iD: 0000-0002-9355-3901
Department of Biological Sciences, National University of Singapore.
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2013 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 8, no 1, e53975- p.Article in journal (Refereed) Published
Abstract [en]

Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese population (948 AR-cases, 580 controls) were analyzed using 49 AR-associated SNPs. The overall pattern of P-values indicated that very few of the investigated SNPs were associated with AR. Given published odds ratios (ORs) most SNPs showed high power to detect an association, but no correlations were found between the ORs of the two study populations or with published ORs. None of the association signals were in common to the two genome-wide association studies published in AR, indicating that the associations represent false positives or have much lower effect-sizes than reported.

Place, publisher, year, edition, pages
2013. Vol. 8, no 1, e53975- p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hkr:diva-10139DOI: 10.1371/journal.pone.0053975ISI: 000315563800027PubMedID: 23382861OAI: oai:DiVA.org:hkr-10139DiVA: diva2:603086
Funder
Swedish Research Council
Available from: 2013-02-05 Created: 2013-02-05 Last updated: 2014-06-10Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
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