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A single-center randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: results after 12 months
Uppsala Käkkirurgiska Centrum.
Kristianstad University, School of Health and Society. (Oral hälsa, Avdelningen för Hälsovetenskap)ORCID iD: 0000-0002-3620-5978
Kristianstad University, School of Health and Society. (Oral hälsa, Avdelningen för Hälsovetenskap)ORCID iD: 0000-0003-0992-2362
2012 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 39, no 7, 666-673 p.Article in journal (Refereed) Published
Abstract [en]

Background Limited evidence exists on the efficacy of regenerative treatment of peri-implantitis Materials and methods Subjects receiving antibiotics and surgical debridement were randomly assigned to placement of autogenous bone (AB) or bovine derived xenograft (BDX) with placement of a collagen membrane. The primary outcome was: evidence of radiographic bone fill and the secondary outcomes included reductions of probing depth (PD) bleeding on probing (BOP) and suppuration. Results 22 subjects were included in the AB and 23 subjects in the BDX group. Statistical analysis failed to demonstrate differences for 38/39 variables assessed at baseline. At 12 months, significant better results were obtained in the BDX group for bone levels (p < 0.001), BOP (p = 0.004), PI (p = 0.003), and suppuration (p < 0.01). When adjusting for number of implants treated per subject, a successful treatment outcome PD≤ 5.0 mm, no pus, no bone loss and BOP at 1/4 sites the likelihood of defect fill was higher in the BDX group (LR: 3.2, 95 % CI: 1.0 to 10.6, p < 0.05). Conclusions Bovine xenograft provided more radiographic bone fill than autogenous bone. The success for both surgical regenerative procedures was limited. Decreases in PD, BOP, and suppuration were observed.

Place, publisher, year, edition, pages
2012. Vol. 39, no 7, 666-673 p.
Keyword [en]
peri-implantitis, peri-implant disease, antibiotics, surgical therapy, bone grafting
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-9195DOI: 10.1111/j.1600-051X.2012.01880.xISI: 000305130000009PubMedID: 22548359OAI: oai:DiVA.org:hkr-9195DiVA: diva2:512842
Available from: 2012-03-29 Created: 2012-03-29 Last updated: 2014-09-18Bibliographically approved

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CiteExportLink to record
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