Rapid globalization and the integration of national economies have contributed to the sharp rise in enrollment in international schools. How does this global nomadism affect international school children and their individual health needs? This study attempts to find an answer by interviewing 10 school nurses, with varying degrees of experience in international schools in Sweden, Germany, and Switzerland. Through qualitative semistructured interviews, the school nurses described that the international school children expressed common health needs similar to the ones faced by children in other school settings. However, children in the international schools expressed additional context-specific health needs related to their transient lifestyle, such as language and cultural difficulties, emotional distress, vulnerability, homesickness, alienation, and increased physical health needs related to their expatriate lifestyle. These factors often present a challenge for the school nurse whose profession is to interpret the child’s health needs, which may be obscured by cultural diversity.