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A systematic study of gene mutations in urothelial carcinoma: inactivating mutations in TSC2 and PIK3R1
Department of Clinical Sciences, Oncology, Lund University.
Department of Clinical Sciences, Oncology, Lund University.
Department of Clinical Sciences, Urology, Skåne University Hospital, Malmö.
Department of Clinical Sciences, Urology, Skåne University Hospital, Malmö.
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2011 (English)In: PloS ONE, ISSN 1932-6203, Vol. 6, no 4, e18583- p.Article in journal (Refereed) Published
Abstract [en]

Our data demonstrate a significant association between FGFR3 and PIK3CA mutations in UC. Moreover, the identification of mutations in PIK3R1 further emphasizes the importance of the PI3-kinase pathway in UC. The presence of TSC2 mutations, in addition to TSC1 mutations, underlines the involvement of mTOR signaling in UC.

Place, publisher, year, edition, pages
2011. Vol. 6, no 4, e18583- p.
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Medical and Health Sciences
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URN: urn:nbn:se:hkr:diva-8156DOI: 10.1371/journal.pone.0018583PubMedID: 21533174OAI: oai:DiVA.org:hkr-8156DiVA: diva2:424411
Available from: 2011-06-20 Created: 2011-06-17 Last updated: 2014-06-10Bibliographically approved

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CiteExportLink to record
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