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A randomized, controlled clinical trial on the clinical, microbiological, and staining effects of a novel 0.05% chlorhexidine/herbal extract and a 0.1% chlorhexidine mouthrinse adjunct to periodontal surgery
Department of Periodontology, Faculty of Medicine, University of Berne.
Department of Periodontology, Faculty of Medicine, University of Berne.
Department of Dentistry, University of Ghent.
Kristianstad University, School of Health and Society. (Oral hälsa)ORCID iD: 0000-0002-3620-5978
2010 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 37, no 11, p. 988-997Article in journal (Refereed) Published
Abstract [en]

Background Chlorhexidine (CHX) rinsing after periodontal surgery is common. We assessed the clinical and microbiological effects of two CHX concentrations following periodontal surgery. Materials and methods In a randomized, controlled clinical trial, 45 subjects were assigned to 4 weeks rinsing with a 0.05 CHX/herbal extract combination (test) or a 0.1% CHX solution. Clinical and staining effects were studied. Subgingival bacteria were assessed using the DNA-DNA checkerboard. Statistics included parametric and non-parametric tests (p < 0001 to declare significance at 80% power). Results At weeks 4 and 12, more staining was found in the control group (p < 0.05 and p < 0.001, respectively). A higher risk for staining was found in the control group (crude OR: 2.3:1, 95% CI: 1.3 to 4.4, p < 0.01). The absolute staining reduction in the test group was 21.1% (9 5% CI: 9.4-32.8%). Probing pocket depth (PPD) decreases were significant (p < 0.001) in both groups and similar (p=0.92). No rinse group differences in changes of bacterial counts for any species were found between baseline and week 12. Conclusions The test CHX rinse resulted in less tooth staining. At the study endpoint, similar and high counts of periodontal pathogens were found.

Place, publisher, year, edition, pages
2010. Vol. 37, no 11, p. 988-997
Keywords [en]
chlorhexidine, gingivitis, herbal extract, microbiota, periodontal, surgery, prevention, plaque, staining, dna-dna hybridization, resistant staphylococcus-aureus, salivary, bacterial counts, chemical plaque control, subgingival microbiota, dental plaque, oral use, 0.12-percent chlorhexidine, 0.2-percent, chlorhexidine, antimicrobial irrigation
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-7521DOI: 10.1111/j.1600-051X.2010.01609.xISI: 000283321400006PubMedID: 20738456OAI: oai:DiVA.org:hkr-7521DiVA, id: diva2:380513
Available from: 2010-12-21 Created: 2010-12-20 Last updated: 2017-12-11Bibliographically approved

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