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Serum uric acid predicts changes in reports of non-gouty chronic pain: a prospective study among women with inflammatory and non-inflammatory pain
Kristianstad University, School of Health and Society. (Avdelningen för Hälsovetenskap)ORCID iD: 0000-0001-9283-5096
Division of Rheumatology, Department of Medicine, Central Hospital, Kristianstad.
2012 (English)In: Rheumatology International, ISSN 0172-8172, E-ISSN 1437-160x, Vol. 32, no 1, 193-198 p.Article in journal (Refereed) Published
Abstract [en]

Widespread pain has earlier been associated with an increase in serum urate (SU). The aim of this study was to longitudinally study the relation between changes in pain reporting and the level of SU among women with chronic pain. Consecutive female patients (n = 124; aged 20-70 years), at rheumatology and rehabilitation practices, with chronic musculoskeletal pain of different origins were followed for 1 year with repeated blood samples and questionnaires. Complete data were obtained from 107 individuals. Factors that predicted an increase in pain extension during 12 months were studied in a logistic regression model. Changes in SU showed a significant correlation (r = 0.36) with changes in the number of reported pain locations. An initially high SU level (OR = 4.46), frequent use of alcohol (OR = 1.32) and a high number of pain locations (OR = 1.24) independently predicted an increase in pain extension during 12 months, whereas the use of steroids (OR = 0.21) in patients with inflammatory disorders resulted in a decreased number of reported pain locations. A relative increase in SU in combination with report of a high number of pain locations turned out to be a risk factor of increased pain extension in a cohort of women with chronic non-gouty pain followed during 1 year. The importance of SU in relation to chronic pain and its prognosis needs to be validated in larger studies.

Place, publisher, year, edition, pages
2012. Vol. 32, no 1, 193-198 p.
Keyword [en]
Uric acid, Non-gouty pain, Pain extension, Widespread pain
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hkr:diva-7231DOI: 10.1007/s00296-010-1600-5ISI: 000299007300031PubMedID: 20803018OAI: oai:DiVA.org:hkr-7231DiVA: diva2:352434
Available from: 2010-09-21 Created: 2010-09-09 Last updated: 2014-01-15Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf