The article builds upon a study where students' relations to science are related to their worldviews and the kind of worldviews they associate with science. The aim of the study is to deepen our knowledge of how worldview and students' ways to handle conflicts between their own worldview and the worldview they associate with science, can add to our understanding of students' relations to science. Data consists of students' responses to a questionnaire (N = 47) and to interviews (N = 26). The study shows that for students who have a high ability in science, those who have taken science-intense programmes in upper secondary school to a higher extent than others have worldviews in accordance with the worldviews they associate with science. This indicates that students who embrace a worldview different from the one they associate with science tend to exclude themselves from science/technology programmes in Swedish upper secondary school. In the article the results are presented through case studies of single individuals. Those students' reasoning is related to the results for the whole student group. Implications for science teaching and for further research are discussed.