This paper is about students’ attitudes towards and interest in science in the lower secondary school in Sweden. The study was part on of a larger project, an evidence-based research project to understand more about how and why students in secondary school develop interest, knowledge and self-efficacy working with socio-scientific issues. The project involved 1427 students completing an attitude questionnaire. Many of the questions have been used in different context and therefore it will also be possible to compare the results from this study with others to see if there are any tendencies of change about students’ attitudes towards and interest in science. The results show that students’ interest to learn more science declined as they progressed through the lower secondary school, Grade 7 to Grade 9, particularly for the girls. Previous studies have also given the same picture. This indicates that school science is an important area that needs to be investigated more on how different learning situations in school affect the attitudes towards science.