Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds 2021 (English)In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, p. 1-14Article in journal (Refereed) Epub ahead of print

Abstract [en]

PURPOSE: To investigate potential interactions between dietary patterns and genetic factors modulating risk for Alzheimer's disease (AD) in relation to incident dementia.

METHODS: Data were derived from the population-based Gothenburg H70 Birth Cohort Studies in Sweden, including 602 dementia-free 70-year-olds (examined 1992-93, or 2000-02; 64% women) followed for incident dementia until 2016. Two factors from a reduced rank regression analysis were translated into dietary patterns, one healthy (e.g., vegetables, fruit, and fish) and one western (e.g., red meat, refined cereals, and full-fat dairy products). Genetic risk was determined by APOE ε4 status and non-APOE AD-polygenic risk scores (AD-PRSs). Gene-diet interactions in relation to incident dementia were analysed with Cox regression models. The interaction p value threshold was < 0.1.

RESULTS: There were interactions between the dietary patterns and APOE ε4 status in relation to incident dementia (interaction p value threshold of < 0.1), while no evidence of interactions were found between the dietary patterns and the AD-PRSs. Those with higher adherence to a healthy dietary pattern had a reduced risk of dementia among ε4 non-carriers (HR: 0.77; 95% CI: 0.61; 0.98), but not among ε4 carriers (HR: 0.86; CI: 0.63; 1.18). Those with a higher adherence to the western dietary pattern had an increased risk of dementia among ε4 carriers (HR: 1.37; 95% CI: 1.05; 1.78), while no association was observed among ε4 non-carriers (HR: 0.99; CI: 0.81; 1.21).

CONCLUSIONS: The results of this study suggest that there is an interplay between dietary patterns and APOE ε4 status in relation to incident dementia.

Place, publisher, year, edition, pages

2021. p. 1-14

Keywords [en]

Apolipoprotein E genotype, Dementia, Dietary pattern, Nutrition, Polygenic risk score

National Category

Neurology Neurosciences

Identifiers

URN: urn:nbn:se:hkr:diva-22620DOI: 10.1007/s00394-021-02688-9ISI: 000705177300001PubMedID: 34632537OAI: oai:DiVA.org:hkr-22620DiVA, id: diva2:1605245

Funder

Alzheimerfonden, AF-842 471Alzheimerfonden, AF-737641Alzheimerfonden, AF-939825Swedish Research Council, 2019-02075Swedish Research Council, 2017-00915The Dementia Association - The National Association for the Rights of the DementedHjalmar Svensson's Research FoundationWilhelm och Martina Lundgrens VetenskapsfondEuropean Commission, 2018-02532European Commission, 11267European Commission, 2005-8460European Commission, 2007-7462European Commission, 2012-5041European Commission, 2015-02830European Commission, 2019-01096European Commission, 2013-8717European Commission, NEAR 2017-00639European CommissionEU, European Research Council, 681712Stiftelsen Gamla Tjänarinnor, FO2019-0228European Commission, 860197Forte, Swedish Research Council for Health, Working Life and Welfare, 2004-0145Forte, Swedish Research Council for Health, Working Life and Welfare, 2006-0596Forte, Swedish Research Council for Health, Working Life and Welfare, 2008-1111Forte, Swedish Research Council for Health, Working Life and Welfare, 2010-0870Forte, Swedish Research Council for Health, Working Life and Welfare, 2013-1202Forte, Swedish Research Council for Health, Working Life and Welfare, 2018-00471Forte, Swedish Research Council for Health, Working Life and Welfare, 20012646Forte, Swedish Research Council for Health, Working Life and Welfare, 2003-0234Forte, Swedish Research Council for Health, Working Life and Welfare, 2004-0150Forte, Swedish Research Council for Health, Working Life and Welfare, 2006-0020Forte, Swedish Research Council for Health, Working Life and Welfare, 2008-1229Forte, Swedish Research Council for Health, Working Life and Welfare, 2012-1138Forte, Swedish Research Council for Health, Working Life and Welfare, AGECAP 2013-2300Forte, Swedish Research Council for Health, Working Life and Welfare, 2013-2496Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, FO2014-0207Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, FO20160214Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, FO2018-0214Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, FO2019-0163Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, FO2020-0235Alzheimerfonden, AF-554461Alzheimerfonden, AF-647651Alzheimerfonden, AF-743701Alzheimerfonden, AF-844671Alzheimerfonden, AF-930868Alzheimerfonden, AF-940139The Swedish Brain Foundation, FO2017-0243Magnus Bergvall FoundationEivind och Elsa K:son Sylvans stiftelse

Note

Övriga forskningsfinaniserärer & strategiska forskningsprojekt:

Open access funding provided by University of Gothenburg. SK was fnanced by grants from the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (ALFGBG-81392, ALF GBG-771071). [...] HZ is a Wallenberg Scholar supported by grants from the Swedish Research Council (2018-02532), the European Research Council (681712), Swedish State Support for Clinical Research (ALFGBG-720931), the Alzheimer Drug Discovery Foundation (ADDF), USA (201809-2016862), the AD Strategic Fund and the Alzheimer’s Association (ADSF-21-831376-C, ADSF-21-831381-C and ADSF-21-831377-C), [...] the Erling-Persson Family Foundation, [...] the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860197 (MIRIADE), and the UK Dementia Research Institute at UCL. IS was fnanced by grants from the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (ALF 716681), Stena Foundation, Swedish Research Council (11267, 2005-8460, 2007-7462, 2012-5041, 2015-02830, 2019-01096, 2013-8717, NEAR 2017-00639), [...] The Alzheimer’s Association Zenith Award (ZEN-01-3151), The Alzheimer's Association Stephanie B. Overstreet Scholars (IIRG-00-2159), The Bank of Sweden Tercentenary Foundation, Stiftelsen Söderström-Königska Sjukhemmet, [...] KB is supported by the Swedish Research Council (2017-00915), the Alzheimer Drug Discovery Foundation (ADDF), USA (RDAPB-201809-2016615), the Swedish Alzheimer Foundation (AF-742881), [...] the Swedish state under the agreement between the Swedish government and the County Councils, the ALF-agreement (ALFGBG-715986), the European Union Joint Program for Neurodegenerative Disorders (JPND2019-466-236), and the National Institute of Health (NIH), USA (grant 1R01AG068398-01). AZ was supported by the Swedish Alzheimer Foundation (AF-930582, AF-646061, AF-741361, AF-939988) [...].

Available from: 2021-10-22 Created: 2021-10-22 Last updated: 2021-10-22Bibliographically approved

Open Access in DiVA

Other links

Publisher's full textPubMed

Authority records

Rothenberg, Elisabet

Search in DiVA

By author/editor

Rothenberg, Elisabet

By organisation

Research Environment Food and Meals in Everyday Life (MEAL)Department of Nursing and Integrated Health SciencesResearch Platform for Collaboration for Health

In the same journal

European Journal of Nutrition

On the subject

NeurologyNeurosciences

Search outside of DiVA

GoogleGoogle ScholarTotal: 152 downloadsTotal: 156 hits