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Hollow-fibre supported liquid membrane extraction for determination of fluoxetine and norfluoxetine concentration at ultra trace level in sewage samples
Division of Analytical Chemistry, Lund University.
Kristianstad University College, Department of Mathematics and Science.
Division of Analytical Chemistry, Lund University.
2007 (English)In: Journal of Separation Science, ISSN 1615-9306, Vol. 30, no 15, 2513-2521 p.Article in journal (Refereed) Published
Abstract [en]

In this study, a method was developed for determining the concentration of the pharmaceutical fluoxetine and its metabolite, norfluoxetine, in sewage water samples. Sample preparation was performed by hollow-fibre supported liquid membrane (HF-SLM) extraction with final analysis using liquid chromatography with UV detection. Several parameters were studied including type of organic solvent, sample and acceptor pH, and salt and humic acid content. The optimised method allowed determination of the analyte at the ng/L level in sewage water. A linear plot gave a correlation coefficient better than 0.991 for both analytes and resulted in limits of detection in sewage water of 11 and 12 ng/L, for fluoxetine and norfluoxetine, respectively. The enrichment factor was over 1700 for both analytes in sewage water. The repeatability and reproducibility were better than 8% and 17%, respectively. The developed methodology was used to study daily variations of fluoxetine and norfluoxetine in municipal sewage streams. Norfluoxetine has been detected for the first time in sewage water and a preliminary analysis gave average concentrations of 150 and 225 ng/L for norfluoxetine and fluoxetine, respectively.

Place, publisher, year, edition, pages
2007. Vol. 30, no 15, 2513-2521 p.
Keyword [en]
Fluoxetine, hollow-fibre, norfluoxetine, occurrence in sewage, supported liquid, membrane extraction, CHROMATOGRAPHY-MASS SPECTROMETRY, SOLID-PHASE EXTRACTION, SEROTONIN, REUPTAKE INHIBITORS, HUMAN PHARMACEUTICALS, WASTE-WATER, ENRICHMENT, TECHNIQUE, TREATMENT PLANTS, AQUEOUS SAMPLES, MICROEXTRACTION, DRUGS
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:hkr:diva-169DOI: 10.1002/jssc.200700165ISI: 000250454100022ISBN: 1615-9306 OAI: oai:DiVA.org:hkr-169DiVA: diva2:160082
Available from: 2009-02-11 Created: 2009-02-11 Last updated: 2009-03-18Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
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