Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes 2021 (English)In: Journal of General Virology, ISSN 0022-1317, E-ISSN 1465-2099, Vol. 102, no 5Article in journal (Refereed) Published

Abstract [en]

Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes patients (n=67) and school children controls (n=292) from Jämtland county in Sweden. NLVA were found in 41 of 67 (61 %) patients compared to 127 of 292 (44 %) controls (P=0.009). In the type 1 diabetes patients, NLVA titres were associated with autoantibodies to glutamic acid decarboxylase (GADA) (P=0.023), but not to autoantibodies against insulin (IAA) or islet antigen-2 (IA-2A). The NLVA assay should prove useful for further investigations to determine levels of LV antibodies in patients and future studies to determine a possible role of LV in autoimmune type 1 diabetes.

Place, publisher, year, edition, pages

2021. Vol. 102, no 5

Keywords [en]

Ljungan Virus, Type 1 diabetes, beta cell autoimmunity, glutamic acid decarboxylase autoantibodies, human pathogen, neutralization assay

National Category

Endocrinology and Diabetes Infectious Medicine

Identifiers

URN: urn:nbn:se:hkr:diva-21920DOI: 10.1099/jgv.0.001602ISI: 000659946800007PubMedID: 34020728OAI: oai:DiVA.org:hkr-21920DiVA, id: diva2:1558248

Funder

Ernfors FoundationStiftelsen Olle Engkvist ByggmästareDiabetesfonden

Note

Erratum: Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes, Annika Lundstig, Sharla L. McDonald, Marlena Maziarz, William C. Weldon, Fariba Vaziri-Sani, Åke Lernmark and Anna-Lena Nilsson, Journal of General Virology 2021;102, doi: 10.1099/jgv.0.001602

In the published version of this article, the second author’s name was listed incorrectly. The author’s name should have been listed as: ‘Sharla L. McDonald’.

The Microbiology Society apologises for any inconvenience caused.

Funding information:

This study was supported by the:

Stiftelsen Axel Tielmans MinnesfondPrinciple Award Recipient: Annika Lundstig

H.K.H. Kronprinsessan Lovisas Förening för Barnasjukvård (SE)Principle Award Recipient: Annika Lundstig

Sven Mattssons Stiftelse Principle Award Recipient: Annika Lundstig

Lunds Revisorer Principle Award Recipient: Annika Lundstig

Lisa och Johan Grönbergs StiftelsePrinciple Award Recipient: Annika Lundstig

Sydvästra Skånes Diabetesförening Principle Award Recipient: Annika Lundstig

Available from: 2021-05-28 Created: 2021-05-28 Last updated: 2021-09-09Bibliographically approved

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Publisher's full textPubMedhttps://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001602

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Faculty of Health Science

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Journal of General Virology

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Endocrinology and DiabetesInfectious Medicine

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