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The severity of human peri-implantitis lesions correlates with the level of submucosal microbial sysbiosis
Tyskland & England.
Tyskland.
Tyskland.
Tyskland & Italien.
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2018 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 45, no 12, p. 1498-1509Article in journal (Refereed) Published
Abstract [en]

AIM: To cross-sectionally analyze the submucosal microbiome of peri-implantitis (PI) lesions at different severity levels.

MATERIALS AND METHODS: Microbial signatures of 45 submucosal plaque samples from untreated peri-implantitis lesions obtained from 30 non-smoking, systemically healthy subjects were assessed by 16s sequencing. Linear mixed models were used to identify taxa with differential abundance by probing depth, after correction for age, gender, and multiple samples per subject. Network analyses were performed to identify groups of taxa with mutual occurrence or exclusion. Subsequently, the effects of peri-implant probing depth on submucosal microbial dysbiosis was calculated using the microbial dysbiosis index.

RESULTS: In total, we identified 337 different taxa in the submucosal microbiome of peri-implantitis. Total abundance of 12 taxa correlated significantly with increasing probing depth; a significant relationship with lower probing depth was found for 16 taxa. Network analysis identified two mutually exclusive complexes associated with shallow pockets and deeper pockets, respectively. Deeper peri-implant pockets were associated with significantly increased dysbiosis.

CONCLUSION: Increases in peri-implant pocket depth are associated with substantial changes in the submucosal microbiome and increasing levels of dysbiosis. This article is protected by copyright. All rights reserved.

Place, publisher, year, edition, pages
2018. Vol. 45, no 12, p. 1498-1509
Keywords [en]
NGS, 16s, dysbiosis, microbiome, next generation sequencing, peri-implant disease, peri-implantitis
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-18790DOI: 10.1111/jcpe.13023ISI: 000453231400011PubMedID: 30341964OAI: oai:DiVA.org:hkr-18790DiVA, id: diva2:1258244
Available from: 2018-10-24 Created: 2018-10-24 Last updated: 2019-01-09Bibliographically approved

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Research environment Oral Health - Public Health - Quality of Life (OHAL)Avdelningen för oral hälsa
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
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  • Other locale
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Output format
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