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High throughput screening method to explore protein interactions with nanoparticles
Lund University.
Upper 2nd school, Klippan, Sweden.
Upper 2nd school, Klippan, Sweden.
Upper 2nd school, Klippan, Sweden.
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2015 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, no 8Article in journal (Refereed) Published
Abstract [en]

The interactions of biological macromolecules with nanoparticles underlie a wide variety of current and future applications in the fields of biotechnology, medicine and bioremediation. The same interactions are also responsible for mediating potential biohazards of nanomaterials. Some applications require that proteins adsorb to the nanomaterial and that the protein resists or undergoes structural rearrangements. This article presents a screening method for detecting nanoparticle-protein partners and conformational changes on time scales ranging from milliseconds to days. Mobile fluorophores are used as reporters to study the interaction between proteins and nanoparticles in a high-throughput manner in multi-well format. Furthermore, the screening method may reveal changes in colloidal stability of nanomaterials depending on the physicochemical conditions.

Place, publisher, year, edition, pages
2015. Vol. 10, no 8
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:hkr:diva-18576DOI: 10.1371/journal.pone.0136687PubMedID: 26313757OAI: oai:DiVA.org:hkr-18576DiVA, id: diva2:1241307
Available from: 2018-08-23 Created: 2018-08-23 Last updated: 2018-08-30Bibliographically approved

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CiteExportLink to record
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  • Other locale
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