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Tillämpad miljöanalytisk kemi för monitorering och åtgärder av antibiotika- och läkemedelsrester i Vattenriket
Kristianstad University, School of Education and Environment, Avdelningen för Naturvetenskap. Kristianstad University, Plattformen för molekylär analys. Kristianstad University, Research environment Man & Biosphere Health (MABH). Lund University.
2016 (Swedish)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Lund: Lund University , 2016. , 144 p.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:hkr:diva-17411Libris ID: 19465333ISBN: 9789176237748 (print)OAI: oai:DiVA.org:hkr-17411DiVA: diva2:1149974
Opponent
Supervisors
Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2017-10-17Bibliographically approved
List of papers
1. Pharmaceutical residues affecting the UNESCO biosphere reserve Kristianstads Vattenrike wetlands: sources and sinks
Open this publication in new window or tab >>Pharmaceutical residues affecting the UNESCO biosphere reserve Kristianstads Vattenrike wetlands: sources and sinks
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2016 (English)In: Archives of Environmental Contamination and Toxicology, ISSN 0090-4341, E-ISSN 1432-0703, Vol. 71, no 3, 423-436 p.Article in journal (Refereed) Published
Abstract [en]

This study is the first to investigate the pharmaceutical burden from point sources affecting the UNESCO Biosphere Reserve Kristianstads Vattenrike, Sweden. The investigated Biosphere Reserve is a >1000 km(2) wetland system with inflows from lakes, rivers, leachate from landfill, and wastewater-treatment plants (WWTPs). We analysed influent and treated wastewater, leachate water, lake, river, and wetland water alongside sediment for six model pharmaceuticals. The two WWTPs investigated released pharmaceutical residues at levels close to those previously observed in Swedish monitoring exercises. Compound-dependent WWTP removal efficiencies ranging from 12 to 100 % for bendroflumethiazide, oxazepam, atenolol, carbamazepine, and diclofenac were observed. Surface-water concentrations in the most affected lake were ≥100 ng/L for the various pharmaceuticals with atenolol showing the highest levels (>300 ng/L). A small risk assessment showed that adverse single-substance toxicity on aquatic organisms within the UNESCO Biosphere Reserve is unlikely. However, the effects of combinations of a large number of known and unknown pharmaceuticals, metals, and nutrients are still unknown.

National Category
Environmental Biotechnology
Identifiers
urn:nbn:se:hkr:diva-15684 (URN)10.1007/s00244-016-0303-7 (DOI)000382937100013 ()27480162 (PubMedID)
Funder
Region Skåne, Regional handlingsplan för läkemedel och miljö, Dnr 1400978Knowledge Foundation, 20120238EU, FP7, Seventh Framework Programme, PIOF-GA-2012-329996
Available from: 2016-08-11 Created: 2016-08-11 Last updated: 2017-10-17Bibliographically approved
2. Describing sorption of pharmaceuticals to lake and river sediments, and sewage sludge from UNESCO Biosphere Reserve Kristianstads Vattenrike by chromatographic asymmetry factors and recovery measurements
Open this publication in new window or tab >>Describing sorption of pharmaceuticals to lake and river sediments, and sewage sludge from UNESCO Biosphere Reserve Kristianstads Vattenrike by chromatographic asymmetry factors and recovery measurements
2015 (English)In: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 415, 73-82 p.Article in journal (Refereed) Published
Abstract [en]

Over the past 30 years a vast number of studies have demonstrated the presence of pharmaceutical residues in the environment. But still knowledge is scarce regarding the interaction of these emerging pollutants with various matrices in nature. A chromatographic system with on-line detection was developed to perform a sorption study of six selected pharmaceuticals to four natural sediments and dewatered digested sewage treatment plant sludge with differing physicochemical characteristics. Sorption effects, measured as asymmetry factors and recoveries, differed pronouncedly among the pharmaceuticals and between the matrices, which could be explained by basic physicochemical properties of the investigated compounds in relation to matrix characteristics. Protonated and deprotonated molecular properties had the greatest importance for sorbate–sorbent interactions. Atenolol, with cationic properties, showed the highest degree of sorption regardless of the matrix studied. Diclofenac and furosemide, both acids, showed the least tendency towards interactions to natural matrices. Among the neutral compounds bendroflumethiazide, carbamazepine and oxazepam, weaker forces, such as van der Waals, aromatic electron donor–acceptor interactions, and hydrogen forces, seemed more important to determine sorption differences. Results revealed that sorption of pharmaceuticals on natural sediments decreased in the order: atenolol (+) > bendroflumethiazide > oxazepam > carbamazepine > diclofenac (−) > furosemide(–). The matrix content of organic matter measured as total organic carbon (TOC) clearly dictated drug sorption. Beside from studying matrix interaction, these results and the developed technique and methodology might find use in the development of new removal processes of pharmaceuticals from wastewater based on improved knowledge concerning chemical interactions to filter materials.

Keyword
Pharmaceutical, sediment, sorption, recovery, asymmetry factor, on-line detection
National Category
Chemical Sciences
Identifiers
urn:nbn:se:hkr:diva-14901 (URN)10.1016/j.chroma.2015.08.061 (DOI)000361865200009 ()26362805 (PubMedID)
Funder
Region Skåne, Regional handlingsplan för läkemedel och miljö Dnr: 1400978Knowledge Foundation, 20120238
Available from: 2015-10-01 Created: 2015-10-01 Last updated: 2017-10-17Bibliographically approved
3. Thermal stability assessment of antibiotics in moderate temperature and subcriticalwater using a pressurized dynamic flow-through system
Open this publication in new window or tab >>Thermal stability assessment of antibiotics in moderate temperature and subcriticalwater using a pressurized dynamic flow-through system
2015 (English)In: International Journal of Innovation and Applied Studies, ISSN 2028-9324, Vol. 11, no 4, 872-880 p.Article in journal (Refereed) Published
Abstract [en]

Thermal degradation of antibiotics has been studied for decades in a broad range of disciplines including food production, agriculture and analytical chemistry. Yet, there is a lack of thermal stability data for many antibiotics. Here we systematically investigated the thermal stability of ten commonly prescribed antibiotics applying a laborsaving automated inhouse pressurized dynamic flow-through system. The design of the system allowed a fast access to a large number of data at medium to subcritical water temperatures, ranging from 50-250 °C. The five ß-lactams cefadroxil, cefuroxime, amoxicillin, penicillin V, and penicillin G showed a high degree of stability with a maximum degradation of less than 30 % at 150 °C. The two quinolones ciprofloxacin and norfloxacin showed a very high thermal stability up to 200 °C, as did trimethoprim andsulfamethoxazole. At 250 °C all antibiotics were either partly of fully removed. The tetracycline doxycycline showed a specific removal pattern probably involving both binding to metal surfaces at lower temperatures as well as degradation at increased temperatures.

Keyword
Antibiotics, ß-lactams, cephalosporins, penicillins, fluoroquinolones, trimethoprim, sulfamethoxazole, thermal stability, subcritical water, dynamic system
National Category
Chemical Sciences
Identifiers
urn:nbn:se:hkr:diva-14900 (URN)
Funder
Knowledge Foundation, 20120238
Available from: 2015-10-01 Created: 2015-10-01 Last updated: 2017-10-17Bibliographically approved

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