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Initial mechanical efficiency of isolated cardiac muscle
Australien.
Australien.
Australien.
2003 (English)In: Journal of Experimental Biology, ISSN 0022-0949, E-ISSN 1477-9145, Vol. 206, no Pt 16, 2725-32 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to determine whether the initial mechanical efficiency (ratio of work output to initial metabolic cost) of isolated cardiac muscle is over 60%, as has been reported previously, or whether it is approximately 30%, as suggested by an estimate based on the well-established net mechanical efficiency (ratio of work output to total, suprabasal energy cost) of 15%. Determination of initial efficiency required separation of the enthalpy output (i.e. heat + work) into initial and recovery components. The former corresponds to energy produced by reactions that use high-energy phosphates and the latter to energy produced in the regeneration of high-energy phosphates. The two components were separated mathematically. Experiments were performed in vitro (30 degrees C) using preparations dissected from rat left ventricular papillary muscles (N=13). Muscle work output and heat production were measured during a series of 40 contractions using a contraction protocol designed to mimic in vivo papillary muscle activity. Net mechanical efficiency was 13.3+/-0.7%. The total enthalpy output was 2.16 times greater than the initial enthalpy output, so that initial mechanical efficiency was 28.1+/-1.2%.

Place, publisher, year, edition, pages
2003. Vol. 206, no Pt 16, 2725-32 p.
Keyword [en]
Muscle energetics; heat production; efficiency; cardiac muscle
National Category
Physiology
Identifiers
URN: urn:nbn:se:hkr:diva-17372DOI: 10.1242/jeb.00480ISI: 000187392900006PubMedID: 12847117OAI: oai:DiVA.org:hkr-17372DiVA: diva2:1147724
Available from: 2017-10-08 Created: 2017-10-08 Last updated: 2017-10-09Bibliographically approved

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Widén, Cecilia
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CiteExportLink to record
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Citation style
  • apa
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  • modern-language-association-8th-edition
  • vancouver
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More styles
Language
  • de-DE
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  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
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  • Other locale
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Output format
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  • asciidoc
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