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Open flap debridement of peri-implantitis with or without adjunctive systemic antibiotics: a randomized clinical trial.
Malmö University.
Kristianstad University, School of Health and Society, Avdelningen för Oral hälsa och folkhälsovetenskap. Kristianstad University, Research environment Oral Health - Public Health - Quality of Life (OHAL).ORCID iD: 0000-0002-3620-5978
Halland's hospital.
Kristianstad University, School of Health and Society, Avdelningen för Oral hälsa och folkhälsovetenskap. Kristianstad University, Research environment Oral Health - Public Health - Quality of Life (OHAL).ORCID iD: 0000-0003-0992-2362
2017 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 44, no 12, p. 1285-1293Article in journal (Refereed) Published
Abstract [en]

AIMS: To investigate clinical, radiographic and microbiological outcome over 12 months following open flap debridement of peri-implantitis with or without antibiotics.

MATERIALS AND METHODS: Peri-implantitis was surgically treated with or without Zithromax(®) in 19 control and 20 test individuals. Probing pocket depth (PPD), gingival inflammation (BOP), intra-oral radiographs and microbial samples were studied. Per protocol, and intent to treat analyzes were performed.

RESULTS: The mean difference (reduction) in PPD values between baseline and month 12 in the test and control groups were: 1.7 mm (SD ± 1.1, 95% CI: 1.1, 2.3, p < 0.001), and 1.6 mm (SD ± 1.5, 95% CI: 0.8, 2,4, p < 0.001), respectively. Data analysis failed to show study group differences for BOP, PPD, radiographic bone level, and microbial load. Succesful treatment (per protocol: PPD≤ 5 mm, no BOP, no suppuration and no bone loss ≥ 0.5 mm) at 12 months in test and control groups were 7/15 (46.7%), and 4/16 (25.0%). Bacterial load reduction was similar in study groups with a temporary reduction following treatment.

CONCLUSIONS: Surgical treatment of peri-implantitis with adjunctive systemic azithromycin did not provide one-year clinical benefits in comparison to those only receiving open flap debridement. This article is protected by copyright. All rights reserved.

Place, publisher, year, edition, pages
2017. Vol. 44, no 12, p. 1285-1293
Keywords [en]
Antibiotics, microbiota, peri-implantitis, surgical treatment
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-17142DOI: 10.1111/jcpe.12805ISI: 000417120000011PubMedID: 28836279OAI: oai:DiVA.org:hkr-17142DiVA, id: diva2:1137079
Available from: 2017-08-30 Created: 2017-08-30 Last updated: 2018-01-09Bibliographically approved

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Persson, Rutger GRenvert, Stefan
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Avdelningen för Oral hälsa och folkhälsovetenskapResearch environment Oral Health - Public Health - Quality of Life (OHAL)
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