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Open flap debridement of peri-implantitis with or without adjunctive systemic antibiotics: a randomized clinical trial.
Malmö University.
Kristianstad University, School of Health and Society, Avdelningen för Oral hälsa och folkhälsovetenskap. Kristianstad University, Research environment Oral Health - Public Health - Quality of Life (OHAL).ORCID iD: 0000-0002-3620-5978
Halland's hospital.
Kristianstad University, School of Health and Society, Avdelningen för Oral hälsa och folkhälsovetenskap. Kristianstad University, Research environment Oral Health - Public Health - Quality of Life (OHAL).ORCID iD: 0000-0003-0992-2362
2017 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051XArticle in journal (Refereed) Epub ahead of print
Abstract [en]

AIMS: To investigate clinical, radiographic and microbiological outcome over 12 months following open flap debridement of peri-implantitis with or without antibiotics.

MATERIALS AND METHODS: Peri-implantitis was surgically treated with or without Zithromax(®) in 19 control and 20 test individuals. Probing pocket depth (PPD), gingival inflammation (BOP), intra-oral radiographs and microbial samples were studied. Per protocol, and intent to treat analyzes were performed.

RESULTS: The mean difference (reduction) in PPD values between baseline and month 12 in the test and control groups were: 1.7 mm (SD ± 1.1, 95% CI: 1.1, 2.3, p < 0.001), and 1.6 mm (SD ± 1.5, 95% CI: 0.8, 2,4, p < 0.001), respectively. Data analysis failed to show study group differences for BOP, PPD, radiographic bone level, and microbial load. Succesful treatment (per protocol: PPD≤ 5 mm, no BOP, no suppuration and no bone loss ≥ 0.5 mm) at 12 months in test and control groups were 7/15 (46.7%), and 4/16 (25.0%). Bacterial load reduction was similar in study groups with a temporary reduction following treatment.

CONCLUSIONS: Surgical treatment of peri-implantitis with adjunctive systemic azithromycin did not provide one-year clinical benefits in comparison to those only receiving open flap debridement. This article is protected by copyright. All rights reserved.

Place, publisher, year, edition, pages
2017.
Keyword [en]
Antibiotics, microbiota, peri-implantitis, surgical treatment
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hkr:diva-17142DOI: 10.1111/jcpe.12805PubMedID: 28836279OAI: oai:DiVA.org:hkr-17142DiVA: diva2:1137079
Available from: 2017-08-30 Created: 2017-08-30 Last updated: 2017-08-30Bibliographically approved

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Avdelningen för Oral hälsa och folkhälsovetenskapResearch environment Oral Health - Public Health - Quality of Life (OHAL)
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