The aim of this study was to identify work and non-work related determinants of mental health problems in Danish workers´ from a pragmatic integrative perspective. A convergent mixed method design consisting of a quantitative (n=391) and qualitative strand (n=10) with integrated interpretation was applied. The determinants of workers´ psychological distress was found to be multi-facetted and multi-contextual. Both strands identified high demands/effort and low social support/reward as important determinants both within and outside the workplace. Moreover it was found that it is the interaction of strains across context that facilitates mental health problems rather than a single element. The mixed method design contributed with an expanded perspective on the complexity of mental health problems among the Danish workers.