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Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders
Norge.
Kristianstad University, School of Education and Environment, Avdelningen för Psykologi. Kristianstad University, Research environment Man & Biosphere Health (MABH).ORCID iD: 0000-0001-6841-1808
Norge.
Norge.
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2016 (English)In: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 12, 389-396 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Schizophrenia is associated with cognitive impairment and brain network dysconnectivity. Recent efforts have explored brain circuits underlying cognitive dysfunction in schizophrenia and documented altered activation of large-scale brain networks, including the task-positive network (TPN) and the task-negative default mode network (DMN) in response to cognitive demands. However, to what extent TPN and DMN dysfunction reflect overlapping mechanisms and are dependent on cognitive state remain to be determined.

METHODS: In the current study, we investigated the recruitment of TPN and DMN using independent component analysis in patients with schizophrenia spectrum disorders (n = 29) and healthy controls (n = 21) during two different executive tasks probing planning/problem-solving and spatial working memory.

RESULTS: We found reduced load-dependent DMN deactivation across tasks in patients compared to controls. Furthermore, we observed only moderate associations between the TPN and DMN activation across groups, implying that the two networks reflect partly independent mechanisms. Additionally, whereas TPN activation was associated with task performance in both tasks, no such associations were found for DMN.

CONCLUSION: These results support a general load-dependent DMN dysfunction in schizophrenia spectrum disorder across two demanding executive tasks that is not merely an epiphenomenon of cognitive dysfunction.

Place, publisher, year, edition, pages
2016. Vol. 12, 389-396 p.
Keyword [en]
Across tasks, Default mode network, Functional magnetic resonance imaging, Independent component analysis, Schizophrenia spectrum disorder, Task-positive network
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:hkr:diva-16224DOI: 10.1016/j.nicl.2016.08.012ISI: 000390196400045PubMedID: 27622135OAI: oai:DiVA.org:hkr-16224DiVA: diva2:1043999
Available from: 2016-11-01 Created: 2016-11-01 Last updated: 2017-04-26Bibliographically approved

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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More styles
Language
  • de-DE
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  • Other locale
More languages
Output format
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