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Påverkan på PK(INR)-värdet efter olika preanalytiska behandlingar i venöst humanblod.
Högskolan Kristianstad, Sektionen för lärande och miljö.
2015 (svensk)Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
Abstract [en]

Venous thromboembolism that cause blood clotting in blood vessels, prevent blood circulation, depending on changes in one or more of the coagulation factors II, VII, IX and X. Patients who have had a blood clot or cardiovascular diseases are treated with oral anti-vitamin K (Warfarin®) to reducing and prevent relapse. Warfarin is also used as a preventive treatment before the disease. An overdose of Warfarin® may cause bleeding-complications and low dose cause blood clotting. The dosage of the drug is controlled by measuring prothrombin in plasma. The aim of this study was to investigate if prothrombin-complex value changes due to re-spinning and re-analysis after six hours. Fitty whole blood samples from warfarin-treated patients were divided into three subgroups, those with protrombinkomplex-values of 2-4 (n=20), >4 (n=15) and <2 (n=15). The samples were centrifugated and measured (Method A), re-centrifugated and measured (Method B) or re-analysed after six hours (Method C). All results were compared in a Bland-Altman plot as follows: Method B vs. Method A and Method C vs. Method A. The scatter graph yielded a strong correlation between Method A and Method B (R2=0.9984) and Method A and Methods C (R2=0.9977). The results from t-test showed a significance level (p<0.001) for both analyses (statistical significance=p<0.05). In this study we showed that prothrombin complex value ware stable after re-centrifugation and re-measurement after six hours. Statistical calculations yielded a strong correlation between the methods (A, B, C), and there was no significance difference between the methods.

sted, utgiver, år, opplag, sider
2015. , s. 22
Emneord [en]
Venous thromboembolism, prothrombin complex, Warfarin®, anti-vitamin K, re-spin, blood clotting, coagulation factors
Emneord [sv]
Venös tromboembolism, protrombinkomplex, antivitamin-K, waran, återcentrifugering, blodproppar, koagulationsfaktorer
HSV kategori
Identifikatorer
URN: urn:nbn:se:hkr:diva-15316OAI: oai:DiVA.org:hkr-15316DiVA, id: diva2:909966
Utdanningsprogram
Bachelor of Science in Biomedical Laboratory Science
Veileder
Examiner
Tilgjengelig fra: 2016-03-08 Laget: 2016-03-07 Sist oppdatert: 2018-01-10bibliografisk kontrollert

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