hkr.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Effect of probiotic lozenges on inflammatory reactions and oral biofilm during experimental gingivitis
Maxillofacial unit, Halland Hospital, Halmstad.
Maxillofacial unit, Halland Hospital, Halmstad.
Department of Dental Medicine, Karolinska Institutet.
Department of Odontology, Oral microbiology, Sahlgenska Academy at Gothenburg University.
Visa övriga samt affilieringar
2013 (Engelska)Ingår i: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 71, nr 3-4, s. 828-833Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aim. Probiotic bacteria have been introduced for prevention and treatment of periodontal diseases. The aim was to assess if daily oral administration of probiotic bacteria could influence the inflammatory response and the composition of supragingival plaque in an experimental gingivitis model. Materials and methods. Eighteen healthy female adults volunteered after informed consent. A double-blind randomized placebo-controlled cross-over design was used. The buccal surface of first molars was used as experimental sites. A mouth-guard covering the first premolar to second molar was used when brushing, preventing accidental cleaning during 3 weeks of plaque accumulation. Lozenges containing L. reuteri (ATCC55730 and ATCC PTA5289) or placebo were taken twice a day. During the run-in and washout periods, professional tooth cleaning was performed 5 days/week. At baseline and follow-up, plaque index, gingival index and bleeding on probing were recorded. Samples of gingival crevicular fluid (GCF) were analysed for concentration of seven inflammatory mediators. Bacterial samples were processed with checkerboard DNA/DNA-hybridization. Results. All subjects presented a local plaque accumulation and developed manifest gingivitis at the test sites during the intervention periods. The volume of GCF increased in both groups but was statistically significant only in the placebo group (p < 0.05). The concentrations of IL1-β and IL-18 increased significantly (p < 0.05), while IL-8 and MIP1-β decreased (p < 0.05). No differences were displayed between test and placebo. Likewise, the microbial composition did not differ between the groups. Conclusion. Daily intake of probiotic lozenges did not seem to significantly affect the plaque accumulation, inflammatory reaction or the composition of the biofilm during experimental gingivitis.

Ort, förlag, år, upplaga, sidor
2013. Vol. 71, nr 3-4, s. 828-833
Nyckelord [en]
bacteriotherapy, cytokines, gingival crevicular fluid, lactobacilli, plaque
Nationell ämneskategori
Odontologi
Identifikatorer
URN: urn:nbn:se:hkr:diva-10497DOI: 10.3109/00016357.2012.734406ISI: 000322832200067PubMedID: 23294143OAI: oai:DiVA.org:hkr-10497DiVA, id: diva2:620217
Tillgänglig från: 2013-05-08 Skapad: 2013-05-08 Senast uppdaterad: 2017-12-06Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Renvert, Stefan

Sök vidare i DiVA

Av författaren/redaktören
Renvert, Stefan
Av organisationen
Avdelningen för HälsovetenskapForskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet
I samma tidskrift
Acta Odontologica Scandinavica
Odontologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 114 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf