hkr.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Rheumatoid arthritis and periodontitis - inflammatory and infectious connections: review of the literature
Högskolan Kristianstad, Sektionen för hälsa och samhälle. (Oral hälsa, Avdelningen för Hälsovetenskap)ORCID-id: 0000-0002-3620-5978
2012 (Engelska)Ingår i: Journal of Oral Microbiology, ISSN 2000-2297, E-ISSN 2000-2297, Vol. 4, s. 11829-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

An association between oral disease/periodontitis and rheumatoid arthritis (RA) has been considered since the early 1820s. The early treatment was tooth eradication. Epidemiological studies suggest that the prevalence of RA and periodontitis may be similar and about 5% of the population are aged 50 years or older. RA is considered as an autoimmune disease whereas periodontitis has an infectious etiology with a complex inflammatory response. Both diseases are chronic and may present with bursts of disease activity. Association studies have suggested odds ratios of having RA and periodontitis varying from 1.8:1 (95% CI: 1.0-3.2, NS) to 8:1 (95% CI: 2.9-22.1, p<0.001). Genetic factors are driving the host responses in both RA and periodontitis. Tumor necrosis factor-α, a proinflammatory cytokine, regulates a cascade of inflammatory events in both RA and periodontitis. Porphyromonas gingivalis is a common pathogen in periodontal infection. P. gingivalis has also been identified in synovial fluid. The specific abilities of P. gingivalis to citrullinate host peptides by proteolytic cleavage at Arg-X peptide bonds by arginine gingipains can induce autoimmune responses in RA through development of anticyclic citrullinated peptide antibodies. In addition, P. gingivalis carries heat shock proteins (HSPs) that may also trigger autoimmune responses in subjects with RA. Data suggest that periodontal therapies combined with routine RA treatments further improve RA status.

CONCLUSIONS: Periodontal infection (P. gingivalis) carries a unique risk for development of autoimmune antibodies associated with RA. Patients with RA have either lost many teeth or usually have severe periodontitis. Additional research, both in regards to basic mechanisms as well as clinical studies, are necessary before it can be said that there are causative links between RA and periodontitis. Cross-disciplinary research in well-defined populations should be performed to further enhance knowledge and develop clinical strategies how to coordinate therapy and risk assessments of RA and periodontitis.

Ort, förlag, år, upplaga, sidor
2012. Vol. 4, s. 11829-
Nyckelord [en]
rheumatoid arthritis, periodontitis, bacteria, inflammation, Porphyromonas gingivalis, citrullination, genetics, review
Nationell ämneskategori
Odontologi
Identifikatorer
URN: urn:nbn:se:hkr:diva-9654DOI: 10.3402/jom.v4i0.11829PubMedID: 22347541OAI: oai:DiVA.org:hkr-9654DiVA, id: diva2:548213
Tillgänglig från: 2012-08-30 Skapad: 2012-08-30 Senast uppdaterad: 2017-12-07Bibliografiskt granskad

Open Access i DiVA

fulltext(1033 kB)446 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1033 kBChecksumma SHA-512
fc14bae74e4180c0f94ab43c045ad7f3fd7e14de5febafc4244e48525085b315d2a8a2d8f9b0f7a91d9acbdc1e1ade3697511f9abea670f448fe92a954dc524c
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Person

Persson, G. Rutger

Sök vidare i DiVA

Av författaren/redaktören
Persson, G. Rutger
Av organisationen
Sektionen för hälsa och samhälle
I samma tidskrift
Journal of Oral Microbiology
Odontologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 446 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 1441 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf